PMID: 8610178Apr 2, 1996Paper

Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation

Proceedings of the National Academy of Sciences of the United States of America
E B CullinanC L Stewart

Abstract

The uterine expression of leukemia inhibitory factor (LIF) is essential for embryo implantation in the mouse. Here, we describe the expression of LIF, related members of this group of cytokines, oncostatin M and ciliary neurotrophic factor, and the LIF receptor beta and glycoprotein gp130 in normal human tissues and in the endometrium of fertile women. Our results show that LIF is the only one of these factors expressed at detectable levels in the endometrium of women of proven fertility. LIF expression is restricted to the endometrial glands during the secretory/postovulatory phase but is not present in the endometrium during the proliferative/preovulatory phase. The LIF receptor beta is expressed during the proliferative and secretory phases of the cycle and is restricted to the luminal epithelium. The associated signal-transducing component of the LIF receptor, gp130, is also expressed in both the luminal and glandular epithelium throughout the cycle. These results suggest that uterine expression of LIF in humans, like mice, may have a role in regulating embryo implantation, possibly through an autocrine/paracrine interaction between LIF and its receptor at the luminal epithelium.

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Citations

Jan 1, 1997·Developmental Genetics·C L Stewart, E B Cullinan
Aug 31, 2002·Molecular Reproduction and Development·Hua NiZeng-Ming Yang
May 29, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sandra M BloisPetra C Arck
Apr 20, 2005·Placenta·T G PoehlmannU R Markert
Jul 26, 2002·Fertility and Sterility·Anette LindhardSteen Sørensen
Mar 7, 2003·Fertility and Sterility·Lusine AghajanovaBritt-Marie Landgren
Jul 10, 2003·Fertility and Sterility·Rebecca L DubowyHarvey J Kliman
Aug 19, 2003·Tissue & Cell·K V R Reddy, Sachin S Mangale
Oct 16, 2003·Placenta·M Cavagna, J C Mantese
Jun 14, 2002·Journal of Reproductive Immunology·Bruce A Lessey
Mar 31, 1999·Immunology Today·J Sánchez-CuencaC Simón
Dec 23, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Thomas SteckJohannes Dietl
Jan 26, 1999·Cytokine & Growth Factor Reviews·A Rice, T Chard
May 22, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Andrew M Sharkey, Stephen K Smith
Feb 7, 2009·Seminars in Reproductive Medicine·Ozlem Guzeloglu-KayisliHugh S Taylor
Jan 17, 2002·The New England Journal of Medicine·E R NorwitzS J Fisher
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sanaz MemarzadehOwen N Witte
May 15, 2008·Human Reproduction·Gayle M JonesAlan O Trounson
Dec 23, 2008·Human Reproduction·Eiji KondohShingo Fujii
Nov 5, 2011·Molecular Human Reproduction·Hitomi NakamuraSarah A Robertson
Sep 22, 2011·Obstetrics and Gynecology·Suleena Kansal KalraKurt T Barnhart
May 8, 2008·Current Opinion in Obstetrics & Gynecology·Kevin S Richter
Apr 1, 1997·American Journal of Reproductive Immunology : AJRI·E Hambartsoumian
Oct 9, 1998·American Journal of Reproductive Immunology : AJRI·M UzumcuJ M Hollanders
Jun 6, 2009·Reproductive Sciences·Jessica G ScotchieSteven L Young
May 31, 2011·Reproductive Biology and Endocrinology : RB&E·Joanne YapEvdokia Dimitriadis
Aug 13, 2011·The Journal of Reproduction and Development·Jumpei TerakawaEiichi Hondo

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