Leukemia inhibitory factor (LIF) promotes the primordial to primary follicle transition in rat ovaries

Molecular and Cellular Endocrinology
Eric NilssonMichael K Skinner

Abstract

In a sexually mature female, primordial follicles continuously leave the arrested pool and undergo the primordial to primary follicle transition. The oocytes increase in size and the surrounding squamous pre-granulosa cells become cuboidal and proliferate to form a layer of cuboidal cells around the growing oocyte. This development of the primordial follicle commits the follicle to undergo the process of folliculogenesis. When the available pool of primordial follicles is depleted reproductive function ceases and humans enter menopause. The current study examines whether leukemia inhibitory factor (LIF) promotes the primordial to primary follicle transition that initiates follicular development. Ovaries from 4 day-old rats were cultured in the absence or presence of LIF or neutralizing antibody to LIF. LIF treatment increased the proportion of follicles that initiated the primordial to primary follicle transition to 59%, compared to 45% in untreated cultured ovaries. The ability of LIF to induce primordial follicle development was enhanced to greater than 75% by the presence of insulin in the culture medium. Anti-LIF neutralizing antibody reduced the proportion of spontaneous developing primordial follicles. Immunocytochemical ...Continue Reading

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Citations

Apr 20, 2005·Molecular and Cellular Endocrinology·Poul Erik HøyerKjeld Møllgård
Jun 29, 2002·Molecular and Cellular Endocrinology·Phillip R KezeleMichael K Skinner
Jun 24, 2003·Animal Reproduction Science·Trudee Fair
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