Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancy

Molecular Reproduction and Development
Z M YangM J Harper

Abstract

Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts. The present study was designed to investigate the changes of LIF protein, LIF receptor, and gp130 in the mouse uterus during the early pregnancy. LIF protein and LIF receptor were at high levels in the mouse uterus near the time of ovulation and on day 4 of pregnancy. gp130 was highest on days 3 and 4 of pregnancy. Both LIF receptor and gp130 showed strong staining in the stroma of the day 5 uterus, at a time when LIF protein was low. The presence of LIF receptor and gp130 in the luminal epithelium on day 4 and in the stroma on day 5 may indicate the site of the high affinity LIF receptor. The coexistence of a high level of LIF protein, LIF receptor, and gp130 in the day 4 uterus is consistent with the previously observed high level of uterine LIF mRNA on the same day and the importance of LIF for the blastocyst implantation in mouse.

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Citations

Jan 1, 1997·Developmental Genetics·C L Stewart, E B Cullinan
Sep 5, 2002·Molecular Reproduction and Development·Li-Juan XiaoZeng-Ming Yang
Aug 31, 2002·Molecular Reproduction and Development·Hua NiZeng-Ming Yang
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Jan 31, 2015·Journal of Molecular Cell Biology·Bo ChuMian Wu
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Jul 28, 2004·Molecular Reproduction and Development·Chun-Bo TengZeng-Ming Yang
May 1, 2012·Molecular Biology Reports·Katarzyna Ropka-MolikAgata Piestrzyńska-Kajtoch
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Apr 1, 1996·Molecular Reproduction and Development·Z M YangM J Harper

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