PMID: 25749520Mar 10, 2015Paper

Leukemia inhibitory factor receptor is a novel immunomarker in distinction of well-differentiated HCC from dysplastic nodules

Oncotarget
Qin LuoWenxin Qin

Abstract

Differential diagnosis of well-differentiated hepatocellular carcinoma (WD-HCC) and high-grade dysplastic nodules (HGDNs) represents a challenge for pathologists. Several immunohistochemistry markers have been identified to distinguish hepatocellular carcinoma (HCC) from HGDNs. However, sensitivity or specificity of the individual marker is still limited. In this study, we analyzed dynamic alteration of leukemia inhibitory factor receptor (LIFR) and CD34 during hepatocarcinogenesis from dysplastic nodules to small HCC. The diagnostic performance of LIFR and CD34 combination in WD-HCC and HGDNs was investigated by logistic regression models and validated in an independent validation cohort. LIFR was decreased and CD34 was increased along with stepwise progression of hepatocarcinogenesis from low-grade dysplastic nodules (LGDNs) to small HCC. The sensitivity and specificity of the LIFR and CD34 combination for WD-HCC detection were 93.5% and 90.5%, respectively. In addition, colony formation assay was used to explore the role of LIFR in tumorigenesis. Silencing of LIFR could significantly promote colony formation of HCC cells, whereas ectopic overexpression of LIFR resulted in impaired ability of colony formation of HCC cells. Th...Continue Reading

References

Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V ParadisP Bedossa
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M RoncalliM Borzio
Dec 20, 2003·Journal of Cancer Research and Clinical Oncology·Zhao-You TangKang-Da Liu
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca Di TommasoMassimo Roncalli
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisa WurmbachJosep M Llovet
Jan 30, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·UNKNOWN International Consensus Group for Hepatocellular NeoplasiaThe International Consensus Group for Hepatocellular Neoplasia
Feb 6, 2009·The American Journal of Surgical Pathology·Péter TátraiIlona Kovalszky
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Luca Di TommasoMassimo Roncalli
Feb 23, 2012·Lancet·Alejandro FornerJordi Bruix
May 15, 2013·Journal of Hepatology·Guang-Zhi JinMeng-Chao Wu
Aug 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jean Charles NaultJessica Zucman-Rossi

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Citations

Jan 25, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Hua LiKai Wang
Dec 25, 2019·Cytokine & Growth Factor Reviews·Vanessa PinhoAndreia C Gomes
May 29, 2021·Seminars in Immunopathology·Dirk Schmidt-ArrasStefan Rose-John
Jul 3, 2021·Nature Reviews. Gastroenterology & Hepatology·Maria D GiraldezMatilde Bustos

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