Leukemia inhibitory factor signaling is required for lung protection during pneumonia.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Lee J QuintonEri Allen

Abstract

Lung infections represent a tremendous disease burden and a leading cause of acute lung injury. STAT3 signaling is essential for controlling lung injury during pneumonia. We previously identified LIF as a prominent STAT3-activating cytokine expressed in the airspaces of pneumonic lungs, but its physiological significance in this setting has never been explored. To do so, Escherichia coli was intratracheally instilled into C57BL/6 mice in the presence of neutralizing anti-LIF IgG or control IgG. Anti-LIF completely eliminated lung LIF detection and markedly exacerbated lung injury compared with control mice as evidenced by airspace albumin content, lung liquid accumulation, and histological analysis. Although lung bacteriology was equivalent between groups, bacteremia was more prevalent with anti-LIF treatment, suggestive of compromised barrier function rather than impaired antibacterial defense as the cause of dissemination. Inflammatory cytokine expression was also exaggerated in anti-LIF-treated lungs, albeit after injury had ensued. Interestingly, alveolar neutrophil recruitment was modestly but significantly reduced compared with control mice despite elevated cytokine levels, indicating that inflammatory injury was not a co...Continue Reading

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Citations

Jul 17, 2012·American Journal of Respiratory and Critical Care Medicine·Joseph P Mizgerd
Feb 19, 2015·American Journal of Respiratory Cell and Molecular Biology·Katrina E TraberLee J Quinton
Jan 22, 2015·American Journal of Respiratory Cell and Molecular Biology·Kristie L HilliardLee J Quinton
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Oct 26, 2021·Frontiers in Microbiology·Ragavan V SureshMeenakshi Malik

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