Leukemic cells with 11q23 translocations express granulocyte colony-stimulating factor (G-CSF) receptor and their proliferation is stimulated with G-CSF

Leukemia
T InukaiS Nakazawa

Abstract

We report a 20-month-old boy with acute lymphoblastic leukemia with the 11q23 translocation whose blasts markedly increased in peripheral blood after intravenous granulocyte colony-stimulating factor (G-CSF) administration, but disappeared after stopping G-CSF. The in vitro study showed that the leukemic cells separated from this patient expressed G-CSF receptor (G-CSFR) and an addition of G-CSF stimulated their proliferation by 3H-thymidine incorporation assay (stimulation index, 4.9). To clarify whether or not leukemic cells with 11q23 translocations generally express G-CSFR and show proliferative response to G-CSF, we performed the similar in vitro experiments using eight leukemic cell lines with 11q23 translocations. We found that all cell lines examined expressed G-CSFR (20-98%) and proliferation of seven leukemic cell lines was significantly enhanced in response to G-CSF (stimulation index >1.5 in five cell lines), suggesting a possible participation of the G-CSF/G-CSFR interaction in the process of growth regulation of leukemic cells with 11q23 translocations.

Citations

May 22, 2008·Pathology Oncology Research : POR·László MárkászEva Oláh
Sep 26, 2015·British Journal of Haematology·Zhouying WuMariko Eguchi
Jan 2, 2008·Leukemia Research·Rudolf BenzJörg Fehr
Feb 24, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christian ProthmannRalph A W Rupp
Jun 17, 2008·Cytokine·Tamila L Kindwall-KellerBelinda R Avalos
Nov 13, 2003·American Journal of Physiology. Renal Physiology·Carsten KneuerWalther Honscha

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