LeukmiR: a database for miRNAs and their targets in acute lymphoblastic leukemia.

Database : the Journal of Biological Databases and Curation
Abdul RawoofLekha Dinesh Kumar

Abstract

Acute lymphoblastic leukemia (ALL) is one of the most common hematological malignancies in children. Recent studies suggest the involvement of multiple microRNAs in the tumorigenesis of various leukemias. However, until now, no comprehensive database exists for miRNAs and their cognate target genes involved specifically in ALL. Therefore, we developed 'LeukmiR' a dynamic database comprising in silico predicted microRNAs, and experimentally validated miRNAs along with the target genes they regulate in mouse and human. LeukmiR is a user-friendly platform with search strings for ALL-associated microRNAs, their sequences, description of target genes, their location on the chromosomes and the corresponding deregulated signaling pathways. For the user query, different search modules exist where either quick search can be carried out using any fuzzy term or by providing exact terms in specific modules. All entries for both human and mouse genomes can be retrieved through multiple options such as miRNA ID, their accession number, sequence, target genes, Ensemble-ID or Entrez-ID. User can also access miRNA: mRNA interaction networks in different signaling pathways, the genomic location of the targeted regions such as 3'UTR, 5'UTR and ex...Continue Reading

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Princess D RodriguezSeth Frietze
Jun 3, 2021·International Journal of Molecular Sciences·Katarzyna GębarowskaMonika Lejman

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Datasets Mentioned

BETA
GSE60386
GSE59199

Software Mentioned

house perl
Perl script
miRecords
miRNAMap
ImaGene
OncomiRdbB
DOSE
PhenomiR
miRGen
MiRCosm

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