PMID: 1195085Jan 1, 1975Paper

Leukocyte alkaline phosphatase in newborn infants after delivery and in the puerperium

Journal of Perinatal Medicine
R HornerW Z Polishuk

Abstract

Leukocyte alkaline phosphatase (LAP) activity increases progressively during pregnancy, returning to non-pregnant levels 6 weeks post-partum. This enzymatic activity is under the influence of placental steroid hormones, thus reflecting placental function. LAP activity is thus a reflection of the dynamic relations between estrogenic, progestational and corticoid activity during pregnancy. LAP activity was studied in 60 women and in their 61 newborn infants at delivery and during the first five days of the puerperium. The Kaplow cytochemical technique was employed. The average maternal LAP score as well as the average newborn infant LAP score was considerably higher than the LAP score of the normal adult. The level of the enzyme in the maternal granulocytes was significantly higher than that of the newborn (Tab. I). During the first five days after labor, there was progressive decrease in the LAP score in the maternal and the newborn blood; on the fifth day the LAP scores of both were only slightly above the normal adult score (Figs. 1, 2). An inverse relation between the LAP score and the birth weight of the infant was found (Tab. III). These results confirm the view that LAP activity in the fetus in utero, are dependent on plac...Continue Reading

References

Jun 15, 1970·American Journal of Obstetrics and Gynecology·W Z PolishukE Sadovsky
Dec 15, 1965·American Journal of Obstetrics and Gynecology·R T O'Kell, L L Axon
May 5, 1960·The New England Journal of Medicine·K R TANAKAR E FREDRICKS

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