Leukocyte analysis of tubulointerstitial nephritis in primary membranoproliferative glomerulonephritis

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
I P NaikerY K Seedat

Abstract

Cellular immune mechanisms may be involved in the pathogenesis of tubulointerstitial nephritis associated with several forms of primary glomerulonephritis. This study aims to characterize the mononuclear leukocytes infiltrating the interstitium in patients with primary membranoproliferative glomerulonephritis (MPGN) and correlates the degree and nature of the infiltrate with renal function. Cellular identification using monoclonal antibodies to leukocyte cell-surface antigens was conducted on renal biopsy specimens from 17 patients with type I primary MPGN (group 1) and 10 controls with various forms of nonproliferative glomerulonephritis (group 2). The majority (14) of the 17 patients in group 1 were black South Africans. Renal function was assessed at the time of renal biopsy. Patients with MPGN had a significant increase in the number of interstitial total leukocytes (LCA), T lymphocytes (T), and B lymphocytes (B) compared with controls. Although the interstitial monocyte (KP(1)) count was also increased in MPGN patients, the difference was not significant. Recorded numbers of cells per square millimeter in group 1 versus group 2 are as follows: LCA, 1306 +/- 1254 versus 138 +/- 91 (P<0.001); T, 638 +/- 547 versus 42 +/- 60 ...Continue Reading

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Citations

Sep 7, 2000·The Veterinary Record·B P Sturgeon, H Bassett
Jul 15, 2005·Kidney International·Kevin Sean Eardley, Paul Cockwell
Aug 4, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M HeinzelmannJ C Passmore

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