Leukocyte Cell-Derived Chemotaxin 2-Associated Renal Amyloidosis: A Case Report

Case Reports in Nephrology and Dialysis
Gagandeep KaurBijin Thajudeen

Abstract

Amyloidosis is a disorder characterized by the deposition of abnormal protein fibrils in tissues. Leukocyte cell-derived chemotaxin 2-associated amyloidosis is a recently recognized entity and is characterized by a distinctive clinicopathologic type of amyloid deposition manifested in adults by varying degrees of impaired kidney function and proteinuria. There are only a limited number of cases reported in the literature. We present a 64-year-old Hispanic female with a history of hypertension who was referred for chronic kidney disease management. The review of her laboratory tests revealed a serum creatinine of 1.5-1.8 mg/dL and microalbuminuria (in the presence of a bland urine sediment) in the past year. She denied any history of diabetes, rheumatologic disorders or exposure to intravenous contrast, nonsteroidal anti-inflammatory drugs, herbals, and heavy metals. Serological workup was negative. A renal biopsy showed diffuse infiltration of glomerulus with pale eosinophilic material strongly positive for Congo red stain and a similar eosinophilic material in the interstitium, muscular arteries, and arterioles. Electron microscopy showed marked infiltration of the mesangium, capillary loops, and interstitium with haphazardly ...Continue Reading

References

Oct 14, 2005·Journal of the American Society of Nephrology : JASN·Gina GregoriniFrancesco Scolari
Nov 10, 2006·Journal of the American Society of Nephrology : JASN·Laura M Dember
May 2, 2008·Kidney International·Merrill D BensonBarbara Kluve-Beckerman
Feb 26, 2010·Kidney International·Christopher P LarsenAlan Solomon
Oct 19, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Charles L MurphyAlan Solomon
Jan 22, 2011·Contributions to Nephrology·Tetsuhiro Tanaka, Masaomi Nangaku
Aug 21, 2013·Proceedings of the National Academy of Sciences of the United States of America·J Paul SimonsPhilip N Hawkins
Feb 14, 2014·Kidney International·Christopher P LarsenPatrick D Walker
Jan 21, 2015·The American Journal of Surgical Pathology·Vishal S ChandanTsung-Teh Wu
Apr 16, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Samih H NasrChristopher P Larsen
Jul 18, 2015·Mediterranean Journal of Hematology and Infectious Diseases·Uday KulkarniVikram Mathews
Feb 13, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher P LarsenSamih H Nasr
Feb 26, 2016·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Christopher P LarsenSarah L Lathrop

❮ Previous
Next ❯

Citations

May 13, 2020·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Michael ShyeRamy M Hanna

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
biopsy
electron microscopy
biopsies

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Revista de investigación clínica; organo del Hospital de Enfermedades de la Nutrición
Victor H Jimenez-Zepeda, Nelson Leung
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Sandra M SoaresFernando C Fervenza
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Y WangY K Zhang
© 2022 Meta ULC. All rights reserved