PMID: 8957373Dec 1, 1996Paper

Leukocyte depletion of blood cardioplegia attenuates reperfusion injury

The Annals of Thoracic Surgery
F E SchmidtRobert A Guyton

Abstract

Leukocytes are associated with myocardial injury during reperfusion after ischemia. Short periods of leukocyte depletion during reperfusion result in persistent attenuation of postischemic myocardial dysfunction. Leukocyte depletion was examined in a canine model of regional myocardial ischemia and reperfusion. The extracorporeal circuit and cardioplegia circuits underwent leukocyte depletion by mechanical filtration. Animals were instrumented for baseline global function before 90-minute occlusion of the left anterior descending coronary artery. Global function during ischemia and at 5, 30, 60, and 90 minutes after a 60-minute cardioplegic arrest using continuous blood cardioplegia was assessed in leukocyte-depleted (n = 9) and control (n = 10) groups. No significant difference between groups was seen for systemic leukocyte counts, global function, or water content. Endothelial function was significantly protected as assessed by response to both calcium ionophore (endothelial-dependent, receptor-independent relaxation: leukocyte-depleted, 72% +/- 19% of endothelin-induced constriction versus control, 46% +/- 14%; p < 0.05) and acetylcholine (endothelial-dependent, receptor-dependent relaxation: leukocyte-depleted, 83% +/- 11% ...Continue Reading

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Citations

Apr 17, 2004·Der Anaesthesist·S PecherM W Hollmann
Feb 27, 2004·Journal of Clinical Anesthesia·Brian M ParkerJ Michael Henderson
Aug 14, 2002·The Annals of Thoracic Surgery·Augustine T M TangSunil K Ohri
Jun 19, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·H YamamotoR Sakata
Jul 30, 2010·Journal of Veterinary Internal Medicine·M A McMichaelT M Fan
Aug 21, 2008·Journal of Cardiothoracic Surgery·Fellery de LangeG Burkhard Mackensen
Apr 20, 2001·Seminars in Thoracic and Cardiovascular Surgery·Y Sawa, H Matsuda
Jul 7, 1999·Journal of Cardiothoracic and Vascular Anesthesia·L K Davies
Sep 22, 2001·Perfusion·G MatheisA Moritz
May 4, 2001·Perfusion·G MatheisA Moritz
Jun 11, 2009·Annals of Biomedical Engineering·Grant J SteyerDavid L Wilson
Jun 28, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Y OkazakiT Itoh
Apr 10, 2004·Perfusion·E M HeerdtD S de Jong
Sep 2, 2000·Anesthesiology·M W Hollmann, M E Durieux
May 15, 2002·Perfusion·George Asimakopoulos

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