PMID: 7086205Jul 1, 1982Paper

Leukocyte effects on the dimorphism of Coccidioides immitis

The Journal of Infectious Diseases
J N GalgianiC M Payne

Abstract

To assess the influences of leukocytes on the dimorphism of Coccidioides immitis, mycelial elements (arthroconidia) or spherules were incubated with polymorphonuclear leukocytes (PMNLs) or mononuclear leukocytes. In the presence of human leukocytes, arthroconidia became separated spherules as determined by electron microscopy but grew as mycelia when viable leukocytes were absent. Plasma was not required for this effect. In a new assay, PMNLs, lymphocytes, or monocytes from human blood as well as rabbit alveolar macrophages inhibited spherules from forming germ tubes. In flat-bottomed glassware, maximal inhibition occurred with PMNL:spherule ratios above 15:1, whereas in conical-bottomed glassware a ratio of 3:1 was maximally suppressive with PMNLs as well as mononuclear leukocytes. Cytochalasin B and colchicine blocked the effect of PMNLs but not that of other blood leukocytes on spherules. These studies indicate that leukocytes influence coccidioidal dimorphism toward the spherule phase. This effect may be important in host defenses against C. immitis.

Citations

Feb 1, 1986·Mycopathologia·R A Fromtling, H J Shadomy
Oct 1, 1988·Diagnostic Microbiology and Infectious Disease·J N GalgianiJ H Law
Jun 1, 1987·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M T LaroccoR J Mandle
Jan 1, 1992·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·M J DolanM G Rinaldi
Oct 19, 2004·Clinical Microbiology Reviews·Rebecca A Cox, D Mitchell Magee
Aug 24, 2010·Autoimmunity Reviews·Andrea T Borchers, M Eric Gershwin
Nov 17, 2004·Mayo Clinic Proceedings·Christina S ReussKevin O Leslie
Apr 23, 2014·BMC Infectious Diseases·Bertha Muñoz-HernándezMaría Angeles Martínez-Rivera
May 15, 2015·PLoS Pathogens·Eric R G LewisBridget M Barker
Feb 8, 2005·PLoS Medicine·Richard F Hector, Rafael Laniado-Laborin
Jun 22, 2019·Journal of Investigative Medicine High Impact Case Reports·Namgyal SherpaRoyce Johnson

Related Concepts

Coccidioides immitis
Colchicine, (R)-Isomer
Cytochalasin B
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
Iodoacetic Acids
Leukocytes
Neutrophil Band Cells

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