PMID: 9450245Feb 5, 1998Paper

Leukocyte emigration in normal calves and calves with leukocyte adhesion deficiency

The Journal of Veterinary Medical Science
H NagahataH Noda

Abstract

The emigration of leukocytes from calves with beta 2 integrin deficiency (BLAD) into bronchoalveolar spaces and scraped tissues was compared to that of normal calves. Polymorphonuclear neutrophils were found in bronchoalveolar lavage fluid from BLAD-affected calves showing chronic pneumonia. The neutrophils were complement receptor type 3 (CR3)-negative when characterized by flow cytometric analysis using anti-CD18 monoclonal antibody. Chemiluminescent response mediated by CR3 in neutrophils isolated from bronchoalveolar lavage fluid from BLAD-calves showed similar findings obtained from CR3-deficient neutrophils. Neutrophils from normal calves migrated into scraped tissue which was prepared in an upper gluteal surface area, whereas few leukocytes from calves with BLAD migrated to the scraped tissue, evaluated by skin window (Rebuck) method. These findings confirmed the extravasation of CR3-deficient leukocytes into bronchoalveolar lumen in BLAD calves, and demonstrated in vivo characteristics of extravasating property of normal and CR3-deficient neutrophils into scraped tissues.

References

Aug 2, 1990·Nature·T A Springer
Aug 1, 1980·The Journal of Infectious Diseases·J C GuckianD P Fine
Mar 1, 1994·The Veterinary Quarterly·E van GarderenT S van den Ingh

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Citations

Jan 13, 2005·The Journal of Veterinary Medical Science·Hajime Nagahata
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·V C RidgerP G Hellewell
Mar 20, 2019·Frontiers in Immunology·Ricardo Grieshaber-Bouyer, Peter A Nigrovic
Feb 16, 2018·Cell and Tissue Research·Laura L Bassel, Jeff L Caswell

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