Leukocyte expression of heme oxygenase-1 [hmox1] varies inversely with severity of tricuspid regurgitation in acute pulmonary embolism

Thrombosis Research
J A KlineHerbert L Bonkovsky

Abstract

Pulmonary embolism (PE) can cause intracardiac hemolysis and increased plasma hemoglobin and arginase-1, which can worsen pulmonary vasoconstriction. We test the hypothesis that patients with PE that causes tricuspid regurgitation (TR), indicative of higher pulmonary arterial pressures, have decreased leukocyte expression of hmox-1 compared with patients with PE and no TR and patients without PE. Prospective, noninterventional study. Normotensive patients with suspected PE (n=87) who underwent CT pulmonary angiography and transthoracic Doppler-echocardiography. Significant TR was defined as a jet velocity >2.7m/s. Leukocyte expression of hmox-1, haptoglobin, haptoglobin related gene, the haptoglobin receptor, CD163 and cox-2 genes were assessed by quantitative rtPCR, and the hmox-1 promoter was examined for the -413 A→T SNP and GT repeat polymorphisms. Of the 44 (50%) with PE+, 22 had TR+, and their mean pulmonary vascular occlusion (39±32%) did not differ significantly from patients who were TR- (28±26%, P=0.15). Patients with PE+ and TR+ had significantly lower expression of hmox-1 and haptoglobin genes than patients without PE+ and no TR. Expression of hmox-1 varied inversely with TR velocity (r(2)=0.45, P<0.001) for PE+ (n=...Continue Reading

References

Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·G NakosM E Lekka
Apr 20, 1999·The Journal of Clinical Investigation·S F YetM E Lee
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·T MinaminoS Kourembanas
Jul 19, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·B WoodhamsY Gourmelin
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 18, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alan E JonesJeffrey A Kline
Mar 3, 2004·Free Radical Biology & Medicine·Mark T GladwinRakesh P Patel
Apr 16, 2004·Transplantation·Markus ExnerOswald F Wagner
Sep 29, 2004·Free Radical Biology & Medicine·Markus ExnerMartin Schillinger
Apr 7, 2005·JAMA : the Journal of the American Medical Association·Russell P RotherMark T Gladwin
Nov 19, 2005·The Journal of Clinical Investigation·Peter C MinneciSteven B Solomon
Oct 3, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Steven DeemErik R Swenson
Oct 19, 2006·Free Radical Biology & Medicine·Anne JeffersDaniel B Kim-Shapiro
Jan 19, 2008·Journal of Vascular Surgery·Stefan MustafaSabine Eichinger
Nov 11, 2008·Medicinal Chemistry·K ShimzuK Morita
Apr 22, 2009·Blood·Marianne Jensby Nielsen, Søren Kragh Moestrup
Jul 2, 2009·Journal of Thrombosis and Haemostasis : JTH·J A KlineM M Hogg
Nov 15, 2011·Pulmonary Pharmacology & Therapeutics·John A WattsJeffrey A Kline
Oct 15, 2013·Journal of Thrombosis and Haemostasis : JTH·J GabreL Zhang
Nov 15, 2013·Critical Care : the Official Journal of the Critical Care Forum·David R JanzLorraine B Ware
Nov 16, 2013·The European Respiratory Journal·Jeffrey A KlineSunil Hwang
Mar 19, 2014·American Journal of Respiratory and Critical Care Medicine·Elizabeth S KlingsUNKNOWN American Thoracic Society Ad Hoc Committee on Pulmonary Hypertension of Sickle Cell Disease
Jan 15, 2015·Proceedings of the National Academy of Sciences of the United States of America·Jenna L LeclercSylvain Doré
Mar 15, 2015·The American Journal of Emergency Medicine·Sotirios KakavasGeorgios Tatsis

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Citations

Mar 18, 2020·Pulmonary Circulation·Mads Dam LyhneAsger Andersen

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