Leukocyte Gene Expression and Plasma Concentration in Multiple Sclerosis: Alteration of Transforming Growth Factor-βs, Claudin-11, and Matrix Metalloproteinase-2

Cellular and Molecular Neurobiology
Gholamreza HassanzadehFatemeh Atoof

Abstract

Multiple sclerosis is a neurodegenerative disease characterized by the present of leukocytes in the brain tissue and subsequently the formation of sclerotic plaques. Leukocytes penetration into the blood-brain barrier is related to several factors, such as, the conversion of leukocyte gene expression or plasma characteristics. In this frame, we explore alteration of matrix metalloproteinase-2 (MMP-2), transforming growth factor beta (TGF-β) family, and Claudin-11 (as a main myelin structural protein) in leukocytes and blood plasma of multiple sclerosis patients compared to the normal group. Blood samples were collected from thirteen men affected by MS and fifteen healthy men. Leukocyte gene expression was measured using real-time PCR and plasma parameters were examined by ELISA. The results of this study showed that the gene expression of Claudin-11 was significantly higher in MS group compared with normal. Interestingly, the MMP-2 pattern was similar to Claudin-11 and correlated positively with it. It was observed that, although the expressions of TGF-β1 and TGF-β2 are down-regulated in the leukocytes of subjects with MS, they showed higher levels of these cytokines in blood plasma. The plasma level of TGF-β3 in MS patients wa...Continue Reading

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·A P KuruvillaG J Thorbecke
Jan 7, 1998·Journal of Neuroscience Research·J M BronsteinK Chen
Jun 16, 2001·International Immunopharmacology·L M OssegeJ P Malin
May 21, 2003·International Journal of Andrology·Wing-Yee LuiC Yan Cheng
Dec 4, 2003·Journal of Neuroscience Research·Lara T DiemelM Louise Cuzner
Mar 27, 2007·Journal of the Neurological Sciences·V Wee YongLuanne M Metz
Mar 26, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick T RonaldsonThomas P Davis
May 8, 2009·Biological & Pharmaceutical Bulletin·Masaya TakeharaTohru Mizushima
Sep 22, 2009·The Journal of Surgical Research·Yongqing LiHasan B Alam
Nov 26, 2010·Journal of Neuroimmunology·Elise M MeoliSteven Jacobson
Jul 19, 2011·Journal of Cellular and Molecular Medicine·Ilana MandelAriel Miller
Sep 4, 2012·International Journal of Molecular Sciences·Arpád DobolyiGábor Lovas
Sep 21, 2012·Neurology·Radoslaw KazmierskiWieslaw L Nowinski
Oct 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wakiro SatoTakashi Yamamura
Sep 5, 2013·Acta neurologica Belgica·Mohammad A JavaidZeeshan Sheikh
Mar 1, 2012·Biomolecules & Therapeutics·Yoon-Seong Kim, Tong H Joh
Dec 10, 2013·Annual Review of Immunology·Mark A Travis, Dean Sheppard
Jan 16, 2014·Pathology Oncology Research : POR·Noor Al-DasooqiRachel J Gibson
Feb 8, 2014·Seminars in Cell & Developmental Biology·Tessa Gaarenstroom, Caroline S Hill

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Citations

Aug 16, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tamires FlauzinoEdna Maria Vissoci Reiche
Sep 5, 2019·Cellular and Molecular Neurobiology·Meysam Moghbeli
Nov 23, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong-Meng ChuangHorng-Jyh Harn

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