Leukocyte Imaging of the Diabetic Foot

Current Pharmaceutical Design
Chiara LauriAlberto Signore

Abstract

Diagnosing diabetic foot infection is often difficult, despite several available diagnostic methods. Amongst these, several imaging modalities exist to evaluate the diabetic foot in case of a suspected osteomyelitis. Nuclear Medicine, in particular, offers a variety of radiopharmaceuticals and techniques. Nowadays the gold standard radionuclide procedure, when an osteomyelitis is suspected, is represented by the use of radiolabelled leukocytes with either 99mTc-HMPAO or 111In-oxine. In this review, we describe the correct acquisition and interpretation of white blood cell scintigraphy and we provide an overview of the existing literature data of the use of this technique in the infected diabetic foot. If images are correctly acquired, displayed and interpreted, this modality reaches very high diagnostic accuracy (>95%) in detecting osteomyelitis and it allows the differential diagnosis with a soft tissue infection or inflammation. Single-photon emission computed tomography/computed tomography (SPECT/CT) in addition to planar images is mandatory to determine the extent and exact location of the infective process in both fore foot and midhint foot. With the addition of bone marrow scintigraphy using radiolabelled nanocolloids, ra...Continue Reading

Citations

Jun 12, 2020·Journal of Clinical Medicine·Chiara LauriLuigi Uccioli
Mar 5, 2021·International Journal of Nanomedicine·Yuxin Liu, Na Wu
Jul 20, 2021·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Massimiliano CasaliAlberto Signore

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