Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.

Blood
David E SloaneJonathan P Arm

Abstract

Basophils, recruited from the blood to tissues, have been implicated by their presence in diverse allergic disorders including bronchial asthma, allergic rhinitis, and cutaneous contact hypersensitivity. We hypothesized that like other leukocytes involved in inflammatory responses, basophils would express members of the leukocyte immunoglobulin-like receptor (LIR) family of immuno-regulatory molecules on their cell surface. We identified LIR7, an activating member coupled to the common Fc receptor gamma chain, and LIR3, an inhibitory member containing cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, on these cells from human peripheral blood. Cross-linking of LIR7 resulted in the concentration-dependent net release of histamine (29.8 +/- 10.8%) and cysteinyl leukotrienes (cysLTs) (31.4 +/- 8.7 ng/10(6) basophils) that were maximal at 30 minutes, and of interleukin-4 (IL-4) (410.2 +/- 61.6 pg/10(6) basophils) that was maximal at 4 hours and comparable with the response initiated by cross-linking of the high-affinity receptor for immunoglobulin E (FcepsilonRI). Coligation of LIR3 to LIR7 or to FcepsilonRI by means of a second monoclonal antibody significantly inhibited net histamine release, cysLT production, and IL-4...Continue Reading

References

Jun 11, 1977·Lancet·L Juhlin, G Michaëlsson
Jan 1, 1992·The Journal of Experimental Medicine·S C Bischoff, C A Dahinden
Mar 1, 1992·The Journal of Clinical Investigation·R AlamJ A Grant
Jan 1, 1990·Springer Seminars in Immunopathology·S M MacDonald, L M Lichtenstein
Mar 1, 1988·The Journal of Allergy and Clinical Immunology·R BascomL M Lichtenstein
Jul 11, 1985·The New England Journal of Medicine·R M NaclerioL M Lichtenstein
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R J SobermanK F Austen
Jul 1, 1971·The New England Journal of Medicine·H F Dvorak, M C Mihm
Feb 1, 1972·The Journal of Experimental Medicine·H F Dvorak, M C Mihm
Aug 4, 1995·Science·S M MacDonaldL M Lichtenstein
Jan 28, 1993·The New England Journal of Medicine·S J Galli
Jan 7, 1998·The Journal of Experimental Medicine·W M Yokoyama
Jan 20, 1999·The Journal of Experimental Medicine·H KubagawaM D Cooper
May 18, 1999·Thorax·N PearceR Beasley
Dec 23, 1999·Current Opinion in Hematology·S J Galli
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J WilsonJ Trowsdale
Aug 10, 2000·The Journal of Allergy and Clinical Immunology·C L KepleyJ M Oliver
Oct 6, 2000·Science·J V Ravetch, L L Lanier
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D SaverinoE Ciccone
Mar 13, 2001·Annual Review of Immunology·J V Ravetch, S Bolland
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y OkayamaD D Metcalfe
Jul 18, 2001·The Journal of Experimental Medicine·M DaheshiaH R Katz
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K MiuraD W MacGlashan
Aug 10, 2001·The Journal of Allergy and Clinical Immunology·K T Nouri-AriaL B Schwartz
Aug 22, 2001·Immunological Reviews·J TrowsdaleM J Wilson
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·C L KepleyM F Lipscomb
Nov 7, 2001·The Journal of Experimental Medicine·M F GurishK F Austen
Feb 13, 2002·The American Journal of Pathology·Nicodemus TedlaJonathan P Arm

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Citations

Apr 6, 2013·Nature Reviews. Immunology·David Voehringer
Apr 11, 2007·The Journal of Experimental Medicine·Ai MasudaToshiyuki Takai
Oct 8, 2013·Journal of Translational Medicine·Maddalena MarchesiGiuseppe V Masucci
Apr 10, 2012·PloS One·Louise HoganRachel L Allen
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yojiro ArinobuKoichi Akashi
Nov 15, 2015·Science China. Life Sciences·FeiFei ZhangChengCheng Zhang
Dec 10, 2009·Developmental and Comparative Immunology·Bettina WagnerDorothy M Ainsworth
May 15, 2007·Immunological Reviews·Jakub Abramson, Israel Pecht
Jun 21, 2011·Immunological Reviews·John T Schroeder
Aug 10, 2016·Frontiers in Immunology·Laura Emily Hudson, Rachel Louise Allen
Jun 24, 2017·Cancer Immunology, Immunotherapy : CII·William van der TouwShu-Hsia Chen
May 6, 2006·The Journal of Biological Chemistry·Mitsunori ShiroishiKatsumi Maenaka
Jan 13, 2017·BioMed Research International·Markus SteinerMartin Himly
Jun 30, 2019·The Journal of Infectious Diseases·Siqi MingXi Huang
Aug 21, 2019·Frontiers in Immunology·Marialbert Acosta-HerreraAna Márquez
May 20, 2020·The Journal of Biological Chemistry·Rika YamazakiKatsumi Maenaka
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donald W MacGlashanDavid E Sloane
May 1, 2021·Antibody Therapeutics·Mi DengCheng Cheng Zhang

❮ Previous
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