PMID: 7546249Apr 1, 1995Paper

Leukocyte subpopulation changes in rats with autotransplanted endometrium and the effect of danazol

American Journal of Reproductive Immunology : AJRI
H MatsubayashiS Nozawa

Abstract

This study examines immune cell populations in rats with autotransplanted endometrium and determines the effect of danazol on leukocyte subsets. As an experimental model of endometriosis, an autologous endometrial segment was implanted in the rat peritoneum. We used flow cytometry to analyze lymphocyte subsets in the peripheral blood (PB) and peritoneal fluid (PF) of the following groups of rats: no treatment, sham operation, endometrial implantation, endometrial implantation treated with danazol, and normal rats treated with danazol. The natural killer (NK) cell population was decreased in both the PB and PF of rats with autotransplanted endometrium. Moreover, NK cells increased in a dose-dependent manner following danazol administration. Surgery itself increased the number of peritoneal macrophages as compared with the untreated group. This elevation was suppressed partially by endometrium-implantation and was attenuated by subsequent administration of danazol in a dose-dependent fashion. These data suggest that ectopic endometrial cells may release immunosuppressive factors. This is the first documentation that rats with autotransplanted endometrium show the same immunologic changes as humans with endometriosis, and establis...Continue Reading

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Citations

Oct 10, 2002·Fertility and Sterility·David Byron Redwine
Nov 2, 2006·The Journal of Reproduction and Development·Ken KusakabeYoshinori Otsuki
Jun 30, 2010·American Journal of Reproductive Immunology : AJRI·Yutaka OsugaYuji Taketani
Feb 2, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·José María R IngelmoPedro Acién

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