PMID: 6983560Dec 1, 1982Paper

Leukocyte subpopulations elicited by a nontumorigenic variant of B16 melanoma: their role in direct rejection of the melanoma and in prevention of tumorigenesis in Winn assays

The Journal of Experimental Medicine
T A CalvelliS Silagi

Abstract

The mechanisms by which various leukocyte subpopulations elicited by an immunogenic, nontumorigenic subclone (C3471) of B16 melanoma caused rejection of the tumorigenic parental melanoma (B559), were investigated. Leukocytes from C3471-immune mice were co-injected with B559 tumor cells in Winn assays into normal syngeneic recipients. Tumor formation by B559 cells was prevented when C3471-immune (a) unfractionated peritoneal leukocytes, or (b) glass-adherent peritoneal cells (90% macrophages), or (c) nylon wool purified nonadherent cells (95% Thy-1.2+) were used in the Winn assays. If the C3471-immunized mice were treated with antithymocyte serum before harvest of their peritoneal cells, none of these leukocyte populations were effective in the Winn assay. However, macrophages from these immunologically compromised donors regained their tumoricidal activity after incubation in vitro with T lymphocytes from untreated C3471-immune donors; similarly, C3471-immune lymphocytes rendered normal resident peritoneal macrophages tumoricidal in Winn assays. When C3471-immunized mice were irradiated or treated with antithymocyte serum before direct challenge with B559 cells, melanomas developed, thus providing additional evidence for the ne...Continue Reading

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Citations

Jan 1, 1985·International Journal of Immunopharmacology·I KatoM Mutai
Feb 15, 1988·International Journal of Cancer. Journal International Du Cancer·S SilagiA Schaefer
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·M Zöller
Dec 15, 1986·International Journal of Cancer. Journal International Du Cancer·F NagaseT Yoshida
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·M GiovarelliG Forni

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