Leukocyte telomere length and epigenetic-based mortality risk score: associations with all-cause mortality among older adults

Epigenetics : Official Journal of the DNA Methylation Society
Xu GaoHermann Brenner

Abstract

Telomere length (TL) has been established as a biomarker of aging and aging-related health outcomes, but showed only a weak or inconsistent association with all-cause mortality in previous epidemiological studies. Recently, an epigenetic 'mortality risk score' (MS) based on whole blood DNA methylation at 10 mortality-related CpG sites has been demonstrated to be strongly related to all-cause mortality at the population level. This study aimed to address the association between TL and this MS, and to assess and compare their associations with all-cause mortality. The MS was derived from the DNA methylation profiles measured by Illumina Human Methylation450K Beadchip and TL was measured by quantitative PCR at baseline among 1517 participants aged 50-75 of the German ESTHER cohort study. In cross-sectional bi- and multivariable analyses, the MS was strongly associated and showed monotonic dose-response relationships with TL (p-values <0.05). However, only the MS but not TL was associated with all-cause mortality during a median follow-up of 12.5 years. After controlling for potential covariates and TL, hazard ratios (95% CI) for all-cause mortality for low, moderate and high levels of the MS defined by 1, 2-5 and >5 CpG sites with...Continue Reading

References

Apr 18, 1991·Nature·E H Blackburn
May 1, 1994·Annals of Epidemiology·J Schwartz, S T Weiss
Jan 1, 1996·Annual Review of Biochemistry·C W Greider
Nov 19, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Abraham Aviv
Nov 11, 2003·Nature·Fabrizio d'Adda di FagagnaStephen P Jackson
Sep 2, 2005·Nature Reviews. Genetics·Maria A Blasco
Jan 19, 2010·Atherosclerosis·Klelia D Salpea, Steve E Humphries
Feb 25, 2010·Heredity·V Bollati, A Baccarelli
Jul 8, 2010·JAMA : the Journal of the American Medical Association·Peter WilleitStefan Kiechl
Oct 30, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Karen Anne MatherHelen Christensen
May 10, 2012·BMC Bioinformatics·Eugene Andres HousemanKarl T Kelsey
Jul 25, 2012·Age and Ageing·Claire Joanne StevesStephen H D Jackson
Nov 28, 2012·Molecular Cell·Gregory HannumKang Zhang
Oct 22, 2013·Genome Biology·Steve Horvath
Sep 18, 2014·Genes·Thomas Mikeska, Jeffrey M Craig
Aug 2, 2015·Current Environmental Health Reports·Christine Ladd-Acosta
Aug 10, 2015·Experimental Gerontology·Aysel MüezzinlerHermann Brenner
Nov 19, 2015·BioMed Research International·Kosuke EndoNaoharu Iwai
Dec 10, 2015·Epigenetics : Official Journal of the DNA Methylation Society·R C HuangK A Lillycrop
Mar 1, 2016·Clinical Epigenetics·Lutz Philipp BreitlingHermann Brenner
Mar 16, 2016·Journal of Immunology Research·Jue LinElizabeth H Blackburn
Apr 15, 2016·International Journal of Epidemiology·Riccardo E MarioniIan J Deary
Mar 18, 2017·Nature Communications·Yan ZhangHermann Brenner
Jul 14, 2017·Environmental Research·Yuliana AstutiUNKNOWN PILAR Research Network

❮ Previous
Next ❯

Citations

Jun 20, 2019·Frontiers in Genetics·Marisa Cañadas-GarreAlexander Peter Maxwell
Feb 9, 2021·Frontiers in Genetics·Alexander Vaiserman, Dmytro Krasnienkov
Apr 7, 2021·Translational Psychiatry·Ekaterina ProtsenkoOwen M Wolkowitz

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

ESTHER
LASSO
GenomeStudio®
SAS

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.