Leukocyte telomere length in patients with bipolar disorder: An updated meta-analysis and subgroup analysis by mood status

Psychiatry Research
Yu-Chi HuangPao-Yen Lin

Abstract

The purpose of the present meta-analysis was to compare leukocyte telomere length (LTL), a proposed marker for cell aging, between patients with bipolar disorder (BD) and healthy controls and explore potential moderators for the LTL difference. We searched for the major research databases up to May 2018 for studies that examined LTL in patients with BD and healthy controls. The effect sizes (ESs) of LTL differences from the included studies were pooled using a random-effects model. Furthermore, we adopted subgroup analysis to investigate whether mood status of BD patients or methods for measuring telomere length may influence such differences. We included 10 studies, with a total of 579 patients and 551 controls, in the current meta-analysis and observed significantly shorter LTL in BD patients compared to control subjects. Such differences were found in studies with patients in all mood statuses and in studies using different methods for measuring telomere length. Late-stage BD patients demonstrated more significant LTL shortening than early-stage BD patients. Our current results support the hypothesis of accelerated aging in BD patients. In the future, further properly controlled longitudinal studies are warranted to determin...Continue Reading

Citations

Jul 30, 2019·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ather Muneer, Fareed Aslam Minhas
Nov 21, 2019·Bipolar Disorders·Gabriel R FriesJoao Quevedo
Aug 20, 2019·Aging·Ake T LuSteve Horvath
Sep 14, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alish B PalmosTimothy R Powell
Apr 9, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Giselli ScainiJoao Quevedo
Jan 23, 2020·Trends in psychiatry and psychotherapy·Elisa BrietzkeFlavio Kapczinski
Sep 11, 2019·Journal of Affective Disorders·Adam FijtmanMárcia Kauer-Sant'Anna
Feb 6, 2020·Neuroscience and Biobehavioral Reviews·Gabriel R FriesJoao Quevedo
Nov 3, 2020·Frontiers in Psychiatry·Martin LundbergMartin Schalling
Jun 10, 2020·Journal of Psychiatric Research·Gabriel R FriesConsuelo Walss-Bass
Apr 18, 2021·L'Encéphale·C CorfdirF Schürhoff
Jun 18, 2021·Neuroscience Letters·Erika M SalardaGabriel R Fries
Jul 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Eun-Jeong JooSoon Ae Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.