Leukocyte telomere length variation in different stages of schizophrenia

Journal of Psychiatric Research
Pawan K MauryaSintia Iole Belangero

Abstract

Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effect of genetic and environmental factors in patients with first-episode psychosis (FEP) and schizophrenia (SCZ). Eighty-one participants with antipsychotic-naïve FEP, 173 with SCZ and 438 HC were enrolled in this study. Psychiatric diagnosis was assessed using the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I). The Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS) and Calgary Depression Scale for Schizophrenia (CDSS) were used to measure symptoms severity. Telomere length (TL) was determined using a multiplex qPCR assay. After adjustment for age, years of education, and smoking status, we found that patients with SCZ had longer TL (relative ratio (RR) = 1.08) than the HC group (RR = 1.00, Wald χ2 = 12.48, p = 0.002). Further, non-remitted SCZ patients presented longer TL (RR = 1.00) compared to remitted SCZ (RR = 0.88, Wald χ2 = 7.20, p = 0.007). TL in patients also correlated to psychopathology assessment in terms of total (p = 0.003) and positive PANSS scores (p = 0.001). No correlation with negative PANSS, YMRS, and CDSS or effects of medication was found on TL. Although...Continue Reading

Citations

Aug 3, 2019·Journal of Attention Disorders·Allison M MomanyHanna Stevens
Mar 23, 2019·Translational Psychiatry·Monica AasOle A Andreassen
Apr 18, 2021·L'Encéphale·C CorfdirF Schürhoff
May 5, 2021·Psychiatry Research·Franck SchürhoffAndrei Szöke
Jul 17, 2021·Psychoneuroendocrinology·Fernanda TalaricoSintia I Belangero
Jan 20, 2022·Rejuvenation Research·Somu Yadav, Pawan Kumar Maurya

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