PMID: 8938203Nov 4, 1996Paper

Leukocyte transmembrane potential in bipolar illness

Journal of Affective Disorders
R S El-MallakhS C Peiper

Abstract

Abnormalities in ion regulation and distribution are commonly reported in bipolar disorder. In an effort to determine if these alter cellular physiological function, we determined the transmembrane potential (TMP) in mononuclear leukocytes from normal individuals and patients with bipolar illness either during normal phase or manic and hypomanic episodes. TMP was analyzed by flow cytometry using dihexyloxacarbocyanine iodide (DIOC6(3)), a cationic potential sensitive fluorescent dye. A normal range was established from measurements on leukocytes from 5 control individuals. TMP of manic and hypomanic patients was significantly hyperpolarized (P = 0.0036). The TMP of euthymic bipolar individuals was not different from normal controls. Pathologic moods in bipolar illness may be associated with altered cellular membrane physiology.

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Citations

Mar 29, 2005·Clinical Psychology Review·Amy K CuellarRay Winters
Nov 23, 2006·Journal of Affective Disorders·Alagu P Thiruvengadam, Krish Chandrasekaran
May 5, 2017·Journal of Central Nervous System Disease·Yonglin GaoRif S El-Mallakh
Apr 25, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Abdallah Barjas Qaswal
Sep 16, 2019·Neuroscience and Biobehavioral Reviews·Aaron A MackRif S El-Mallakh
Jan 31, 2021·Medical Hypotheses·Rif S El-Mallakh, Ziad Ali

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