Leukocytoclastic vasculitis associated with immunoglobulin A lambda monoclonal gammopathy of undetermined significance: A case report and review of previously reported cases

The Journal of Dermatology
Hiroshi UmemuraKeiji Iwatsuki

Abstract

Leukocytoclastic vasculitis is often associated with immunoglobulin (Ig)A deposition on the vascular walls. IgA-associated leukocytoclastic vasculitis comprises various underlying diseases. Hematological disorders that can be minor triggers include multiple myeloma and monoclonal gammopathy of undetermined significance. Here, we present the case of a 78-year-old woman with leukocytoclastic vasculitis associated with monoclonal gammopathy of undetermined significance of the IgA lambda chain. Oral steroid administration initially showed remission of vasculitis; however, the condition recurred after four attempts of treatment withdrawal. We also reviewed previous reports of 14 cases of IgA-associated leukocytoclastic vasculitis, of which 11 were associated with multiple myeloma and three with monoclonal gammopathy of undetermined significance.

References

Nov 1, 1986·Annals of Internal Medicine·J J McMillenG A Dyer
Feb 1, 1987·Annals of Internal Medicine
Apr 29, 1998·Journal of the European Academy of Dermatology and Venereology : JEADV·B AkpunonuB Kahaleh
Sep 8, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A M ZickermanJ Feehally
Mar 19, 2003·Journal of Cutaneous Pathology·A Neil CrowsonCynthia M Magro
Jul 5, 2003·Annals of Hematology·P ArrizabalagaJ Bladé
Sep 3, 2003·Clinical and Experimental Dermatology·I B Bayer-Garner, B R Smoller
Sep 6, 2003·British Journal of Haematology·Annette H M Van Der Helm-Van MilHeroen C J Eikenboom
Mar 9, 2011·European Journal of Dermatology : EJD·Marta CarlesimoGermana Camplone
Jul 7, 2011·Clinical Lymphoma, Myeloma & Leukemia·Pierre PeterlinChristian Agard
Aug 9, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·D Lipsker
Jun 28, 2017·Acta Dermato-venereologica·Liv Eline HetlandAnette Bygum
Nov 9, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·L RoussetJ-D Bouaziz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.