Leukodepletion for acute lymphocytic leukemia in a three-week-old infant

Journal of Clinical Apheresis
S WoloskieD Haas

Abstract

We report the smallest infant (4.5 kg) to receive leukapheresis as an immediate treatment for Infantile Acute Lymphocytic Leukemia. Leukodepletion helps prevent the risks of hyperviscosity and cerebrovascular and pulmonary leukostasis. In addition, it is a desirable precursor to chemotherapy to potentially reduce metabolic and renal complications associated with rapid cell lysis. Because of this infant's small size, she presented us with multiple concerns, including hypocalcemia from citrate anticoagulation, extracorporeal volume and fluid balance, inlet flow rates. and establishment of adequate interface. Our positive experience in performing this procedure suggests that cytapheresis is a feasible treatment even for very young infants.

Citations

Apr 30, 2003·Journal of Clinical Apheresis·Naohide AgeyamaKeiji Terao
Nov 18, 2008·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Volker WittJ Tomaz
Jan 23, 2016·Journal of Pediatric Hematology/oncology·Oussama AblaAhmed Naqvi
Jun 18, 2014·Journal of Pediatric Hematology/oncology·Victoria GrèzeJustyna Kanold

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.