PMID: 485741Oct 1, 1979

Leukopenia and hypoxemia. Unrelated effects of hemodialysis

Archives of Internal Medicine
F Dumler, N W Levin

Abstract

Hemodialysis-induced hypoxemia has been attributed to membrane-related complement activation leading to pulmonary leukostasis and to hypoventilation secondary to carbon dioxide losses via the dialyzer. We have separately assessed the role of membrane- and dialysis-related factors by using different dialyzers and sequential ultrafiltration and hemodialysis with first-use cellulose dialyzers produced both leukopenia and hypoxemia. With reused cellulose and polyacrylonitrile dialyzers, hypoxemia still occurred, but without leukopenia. Ultrafiltration produced leukopenia and no changes in Pao2; during the subsequent hemodialysis, hypoxemia developed as the leukocyte count increased by 50%. Our data indicate that leukopenia and hypoxemia are unrelated effects of hemodialysis, and favor hypoventilation as the major determinant of hypoxemia during hemodialysis.

Citations

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Related Concepts

Anoxemia
Hemodialysis
Renal Dialysis Machine
Differential White Blood Cell Count Procedure
Leukopenia
Membranes, Artificial
Ultrafiltration

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