Leukotriene C4 in children with atopic asthma. I. Plasma levels in acute asthma

Acta Paediatrica Japonica; Overseas Edition
E Iwasaki

Abstract

The leukotrienes C4, D4 and E4 are potent biologic mediators, and are thought to play an important role in obstructive airways disease such as asthma. In this study, plasma immunoreactive LTC4 (iLTC4) levels in asthmatic children were measured using radioimmunoassay after Sep-pak extraction in order to determine whether LTC4 is released in vivo during an asthmatic attack. In 10 non-atopic children, the mean +/- SEM of plasma iLTC4 level was 0.031 +/- 0.013 pmol/ml. Significantly higher plasma iLTC4 levels were recognized at all stages in asthmatic children, both in remission (p less than 0.01) and during an attack (p less than 0.01). PaO2 levels during an attack were significantly lower in the high iLTC4 group. In 15 asthmatic children, the plasma iLTC4 levels during an attack (0.134 +/- 0.017 pmol/ml) significantly decreased during recovery (0.078 +/- 0.012 pmol/ml) (p less than 0.05). Plasma iLTC4 levels correlated closely with lung function (p less than 0.01). The high iLTC4 levels in plasma in asthmatic children suggest a role for LTC4 in the pathophysiology of asthma.

References

Jan 1, 1987·International Archives of Allergy and Applied Immunology·T OkuboS Suzuki
Feb 1, 1985·The Tohoku Journal of Experimental Medicine·H OhtsuT Takishima
Jul 16, 1985·Biochemical and Biophysical Research Communications·T IsonoS Furukawa
Nov 30, 1984·Biochemical and Biophysical Research Communications·B C BeaubienH R Morris
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S E DahlénB Dahlén
Feb 24, 1983·The New England Journal of Medicine·M GriffinJ M Drazen
May 1, 1982·Canadian Journal of Physiology and Pharmacology·T R JonesE E Daniel

❮ Previous
Next ❯

Citations

Sep 1, 1995·Archives of Disease in Childhood·A P SampsonJ F Price
Feb 13, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Elizabeth Hernández-AlvídrezMario H Vargas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.