Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells.

The Journal of Biological Chemistry
Sailaja ParuchuriJoshua A Boyce

Abstract

Cysteinyl leukotrienes (cys-LTs) are potent inflammatory lipid mediators, of which leukotriene (LT) E(4) is the most stable and abundant in vivo. Although only a weak agonist of established G protein-coupled receptors (GPCRs) for cys-LTs, LTE(4) potentiates airway hyper-responsiveness (AHR) by a cyclooxygenase (COX)-dependent mechanism and induces bronchial eosinophilia. We now report that LTE(4) activates human mast cells (MCs) by a pathway involving cooperation between an MK571-sensitive GPCR and peroxisome proliferator-activated receptor (PPAR)gamma, a nuclear receptor for dietary lipids. Although LTD(4) is more potent than LTE(4) for inducing calcium flux by the human MC sarcoma line LAD2, LTE(4) is more potent for inducing proliferation and chemokine generation, and is at least as potent for upregulating COX-2 expression and causing prostaglandin D(2) (PGD(2)) generation. LTE(4) caused phosphorylation of extracellular signal-regulated kinase (ERK), p90RSK, and cyclic AMP-regulated-binding protein (CREB). ERK activation in response to LTE(4), but not to LTD(4), was resistant to inhibitors of phosphoinositol 3-kinase. LTE(4)-mediated COX-2 induction, PGD(2) generation, and ERK phosphorylation were all sensitive to interferen...Continue Reading

References

Jul 1, 1992·The American Review of Respiratory Disease·J M DrazenC H Fanta
Dec 1, 1992·The American Review of Respiratory Disease·P E ChristieT H Lee
Nov 1, 1991·The American Review of Respiratory Disease·S P O'HickeyT H Lee
Oct 1, 1987·The American Review of Respiratory Disease·J M Drazen, K F Austen
Jul 26, 1984·The New England Journal of Medicine·C C HardyS T Holgate
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·S A KliewerR M Evans
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·B K LamK F Austen
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D W NicholsonA W Ford-Hutchinson
May 16, 1997·The Journal of Biological Chemistry·C L Rokos, B J Ledwith
Mar 21, 1998·The Journal of Clinical Investigation·A S CowburnA P Sampson
Jun 14, 2000·The Journal of Biological Chemistry·C E HeiseJ F Evans
Dec 5, 2000·Current Opinion in Immunology·J WedemeyerS J Galli
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·E A MellorJ A Boyce
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·G M GauvreauP M O'Byrne
Nov 8, 2002·The New England Journal of Medicine·Ana R SousaTak H Lee
Feb 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ouliana ZiouzenkovaJorge Plutzky
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth A MellorJoshua A Boyce
Oct 2, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D J FigueroaJ F Evans
Feb 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Thomas C BellerYoshihide Kanaoka
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshihide Kanaoka, Joshua A Boyce
Aug 21, 2004·Blood·Savita BaggaJoshua A Boyce
May 21, 2005·Molecular Pharmacology·J Alberto Olivares-ReyesKevin J Catt
Nov 11, 2005·Biochemical Pharmacology·Liaman MamedovaKenneth A Jacobson
Mar 10, 2006·The Journal of Biological Chemistry·Koichiro WadaRichard S Blumberg
Mar 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel C KimYoshihide Kanaoka

❮ Previous
Next ❯

Citations

Apr 30, 2011·Chemical Reviews·Motonao Nakamura, Takao Shimizu
Oct 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Akiko MaekawaK Frank Austen
Apr 2, 2011·The Journal of Biological Chemistry·Hiromichi SainoMasashi Miyano
Oct 14, 2009·The Journal of Experimental Medicine·Sailaja ParuchuriJoshua A Boyce
Mar 31, 2011·Journal of Leukocyte Biology·Mari KogisoYoshimi Shibata
Jan 8, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshitaka Taketomi, Makoto Murakami
Mar 14, 2009·The Tohoku Journal of Experimental Medicine·Izumi KanekoMasao Ono
Jul 15, 2015·European Journal of Pharmacology·Yingxin YuFrank A Redegeld
Sep 13, 2011·Blood·Christian A KunderSoman N Abraham
Apr 29, 2014·Prostaglandins, Leukotrienes, and Essential Fatty Acids·John W SteinkeLarry Borish
Aug 4, 2009·The Journal of Allergy and Clinical Immunology·K Frank AustenJoshua A Boyce
Jul 19, 2016·Oral Diseases·S Sommakia, O J Baker
Jul 2, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sean J LundTaylor A Doherty
Sep 22, 2011·Anesthesiology·Bodil PetersenWarren M Zapol
Aug 29, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T M Laidlaw, J A Boyce
Oct 27, 2018·International Journal of Molecular Sciences·Thomas SonnweberIvan Tancevski
Dec 27, 2019·Allergy·Jiao XiaGrzegorz Woszczek
May 4, 2010·Platelets·Shunji HasegawaSusumu Furukawa
Dec 4, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea MagroneEmilio Jirillo
May 26, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Noritaka HigashiKazuo Akiyama
Jun 14, 2017·Mediators of Inflammation·Paolo GelosaLaura Castiglioni
Sep 22, 2017·Mediators of Inflammation·Francesca ColazzoLaura Castiglioni
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Ernest DuahSailaja Paruchuri
Mar 20, 2019·Medical Sciences : Open Access Journal·Kevin L LiWaleed M Abuzeid
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yongfeng JiangJoshua A Boyce
Sep 24, 2015·IUBMB Life·Rachel Marion-LetellierSubrata Ghosh
Apr 5, 2016·Biological & Pharmaceutical Bulletin·Mofei WangYasutaka Kurata
Oct 12, 2017·Lipids in Health and Disease·Luca NavariniDomenico Paolo Emanuele Margiotta
Feb 13, 2018·Immunological Reviews·Frank A RedegeldUlrich Blank
May 15, 2018·The Journal of Clinical Investigation·Takehiko YokomizoTakao Shimizu
Jun 14, 2019·Frontiers in Immunology·Erika Méndez-Enríquez, Jenny Hallgren
Jan 20, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Grzegorz WoszczekJames H Shelhamer
Jul 14, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Fang DuZeng-Jie Yang
Dec 8, 2020·The Journal of Allergy and Clinical Immunology·Tao LiuJoshua A Boyce
Mar 25, 2021·The Journal of Allergy and Clinical Immunology·Claus BachertWilliam W Busse

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.