Leukotriene inhibitors and non-steroidal therapies in the treatment of asthma

Expert Opinion on Pharmacotherapy
M E Krawiec, S E Wenzel

Abstract

Asthma is the most common chronic disease of childhood whose morbidity and mortality continues to rise [1]. Drugs used in the treatment of asthma must be targeted at reversing three principle pathophysiologic features: bronchoconstriction, mucus plugging/hypersecretion and inflammation. In the past two decades, the contribution of airway inflammation to the development and progression of asthma symptoms and airway pathology has become a critical focus. Chronic airway inflammation can lead to the progressive decline and irreversible loss of lung function and airway remodelling [2]. In recent years, therapies aimed at diminishing airway inflammation have been at the forefront of asthma management. Steroids have been extensively studied and used as primary anti-inflammatory agents in the management of the asthmatic patient with persistent symptoms of varying severity. Within the last decade, however, several additional non-steroidal classes of drugs have begun to emerge as anti-inflammatory agents for the treatment of asthma. This article will focus on these non-steroidal drugs which have been developed and investigated within the last 5 years. Particular emphasis will be placed on leukotriene receptor antagonists, but anti-IgE an...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R C MurphyB Samuelsson
Jun 1, 1992·The Journal of Allergy and Clinical Immunology·Y KikawaM Sudo
Dec 1, 1991·The American Review of Respiratory Disease·C M SmithT H Lee
Jan 1, 1991·International Archives of Allergy and Applied Immunology·A Foster, C C Chan
Dec 20, 1990·The New England Journal of Medicine·P J ManningP M O'Byrne
Feb 2, 1989·The New England Journal of Medicine·B BurrowsM G Cline
Mar 1, 1989·The American Review of Respiratory Disease·R BeasleyS T Holgate
Sep 1, 1987·The American Review of Respiratory Disease·P M O'ByrneF E Hargreave
Dec 4, 1980·Nature·S E DahlénB Samuelsson
Feb 1, 1982·The Journal of Experimental Medicine·A JörgS J Klebanoff
Jan 8, 1981·The New England Journal of Medicine·E G NassifW Huntley
May 1, 1995·International Archives of Allergy and Immunology·R L ShieldsP Jardieu
Sep 1, 1995·American Journal of Respiratory and Critical Care Medicine·S E WenzelJ Y Westcott
Jan 19, 1995·The New England Journal of Medicine·F D MartinezW J Morgan
Feb 1, 1994·Pulmonary Pharmacology·C R TurnerJ W Watson
May 12, 1994·The New England Journal of Medicine·E R McFadden, I A Gilbert
May 1, 1994·American Journal of Respiratory and Critical Care Medicine·C R TurnerJ W Watson
Dec 1, 1993·Annals of Internal Medicine·E IsraelJ M Drazen
Apr 1, 1993·The American Review of Respiratory Disease·B S FriedmanP Sterk
Oct 1, 1993·European Journal of Immunology·K A Yamaoka, J P Kolb
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·S S MeltzerE R Bleecker
Jul 1, 1996·The Journal of Allergy and Clinical Immunology·S T HolgateA P Sampson
Dec 1, 1996·American Journal of Respiratory and Critical Care Medicine·A SzczeklikJ Oates
Jan 1, 1997·Clinical Pharmacology and Therapeutics·I De LepeleireM Decramer

❮ Previous
Next ❯

Citations

Mar 18, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Ernesto G OcchiatoMario Serio
Aug 27, 2005·American Journal of Respiratory Cell and Molecular Biology·Jie ZhuPeter K Jeffery
Nov 22, 2008·Pulmonary Pharmacology & Therapeutics·Alaina J AmmitSuzanne Zuyderduyn
Jan 19, 2006·Journal of Ethnopharmacology·Marit-Saskia Wahrendorf, Michael Wink
May 5, 2001·Expert Opinion on Pharmacotherapy·A Bennett
Mar 5, 2009·The American Journal of Forensic Medicine and Pathology·Carlo P CampobassoMarina Caligara
Dec 17, 2009·Progress in Cardiovascular Nursing·Laura J WentworthBrent A Bauer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.