Leukotrienes and inflammation

Pharmacology & Therapeutics
S D Brain, T J Williams

Abstract

The leukotrienes are synthesized from essential fatty acids via a 5-lipoxygenase enzyme. Most is known about the four-series leukotrienes derived from arachidonic acid. Leukotriene B4 is a potent chemotactic agent for leukocytes and it induces neutrophil-dependent increased microvascular permeability. Leukotrienes C4, D4 and E4 are bronchoconstrictors; and potent mediators of microvascular tone and permeability. The leukotrienes have been suggested to have a role in many inflammatory conditions in man in the skin (e.g. psoriasis), the lung (e.g. allergic asthma), joints (e.g. rheumatoid arthritis) and in the heart (e.g. myocardial infarction). Drugs which inhibit the generation and the actions of leukotrienes are under development and are being tested clinically as potential anti-inflammatory agents.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R C MurphyB Samuelsson
Jun 1, 1979·Prostaglandins·B SamuelssonR C Murphy
Jul 1, 1978·Prostaglandins·S H FerreiraM S de Abreu Castro
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·P Borgeat, B Samuelsson
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S HammarströmJ J Voorhees
Aug 1, 1985·The Journal of Clinical Investigation·S F TalbotB Zweiman
Apr 1, 1987·British Medical Bulletin·R D Camp, M W Greaves
Apr 1, 1987·British Medical Bulletin·B HendersonG A Higgs
Jan 1, 1986·Progress in Lipid Research·B Samuelsson
Feb 1, 1985·The Journal of Investigative Dermatology·C C Chan, A Ford-Hutchinson
May 1, 1985·The Journal of Investigative Dermatology·E WongM W Greaves
Apr 1, 1985·Prostaglandins·S D BrainS Charleson
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·F Arenzana-SeisdedosJ L Virelizier
Oct 1, 1987·Acta Paediatrica Japonica; Overseas Edition·J P Arm, T H Lee
Apr 1, 1988·The Journal of Allergy and Clinical Immunology·S LamH Salari
Apr 14, 1986·Biochemical and Biophysical Research Communications·P M Woollard
Aug 27, 1985·European Journal of Pharmacology·S Barst, K Mullane
Jun 1, 1985·The Journal of Investigative Dermatology·P M DowdM W Greaves
Jan 1, 1969·European Journal of Pharmacology·W H FunderburkJ W Ward
Jan 1, 1969·Advances in Immunology·R P Orange, K F Austen
Sep 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M Hamberg, B Samuelsson
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·C N SerhanB Samuelsson
Sep 1, 1984·British Journal of Pharmacology·S D BrainA K Black
Oct 1, 1984·European Journal of Pharmacology·A SchweizerM A Bray
Sep 1, 1981·The Journal of Pharmacy and Pharmacology·S A Rae, M J Smith
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M E AndersonA Meister
Jun 1, 1982·The Journal of Pharmacy and Pharmacology·E M DavidsonM J Smith

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Citations

Sep 1, 1992·Medicinal Research Reviews·A Barber, R Gottschlich
Nov 1, 1993·Journal of Clinical Immunology·L L WilliamsF S Wright
Sep 1, 1991·Agents and Actions·D M RolandT J Kowalski
Jan 5, 1996·Biochimica Et Biophysica Acta·F H ChiltonJ D Winkler
Oct 12, 2002·Paediatric Respiratory Reviews·John W Wilson, Colin F Robertson
Feb 13, 2001·The British Journal of Dermatology·T HishinumaM Mizugaki
Jun 1, 1993·The British Journal of Dermatology·J FaulerJ Frölich
Jun 1, 1995·European Journal of Biochemistry·T HammarbergB Samuelsson
Sep 25, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·C V ChandrasekaranAmit Agarwal
Aug 13, 2011·Neuropathology and Applied Neurobiology·C VoigtM U Schuhmann
Jul 1, 1996·The Annals of Thoracic Surgery·R J NovickJ Lee
Oct 1, 1993·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S Hyslop, G De Nucci
Nov 30, 2010·Journal of Molecular and Cellular Cardiology·Ulrich M BecherCornelius F H Mueller
Nov 4, 2000·Expert Opinion on Investigational Drugs·J B Travers
Jun 7, 2015·Archives of Pharmacal Research·Jean Paul DzoyemJacobus N Eloff
Aug 14, 1992·Biochemical and Biophysical Research Communications·M D Percival, M Ouellet
Oct 1, 1994·Human & Experimental Toxicology·P M Hext
Nov 3, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Jae Chun LimUy Dong Sohn
Apr 11, 2018·Journal of Cosmetic Dermatology·V ArunaR Gayathri
May 30, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masanao Inagaki
May 20, 2018·International Journal of Clinical Pharmacy·Weng Khong Chin, Shaun Wen Huey Lee
Jan 6, 2006·Journal of Medicinal Chemistry·Caroline CharlierJohan Wouters
Aug 6, 2008·Journal of Agricultural and Food Chemistry·Long Shuang HuangDai-Eun Sok

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