Leukotrienes in patients with clinically active multiple sclerosis

Acta Neurologica Scandinavica
I NeuE Mayatepek

Abstract

The role of leukotrienes (LTs) in the pathophysiology of multiple sclerosis (MS) has been controversially discussed in the past. Studies of LTs in the cerebrospinal fluid (CSF) revealed different results mainly because of analytical difficulties. In the present study we used highly sensitive and specific analytical methods for measuring LTs in the CSF as well as in urine samples from 20 patients with active MS and 20 control patients with noninflammatory neurological disorders. LTB4 concentrations in CSF were almost twice as high in MS patients compared with controls (P < 0.001). CSF concentrations of the cysteinyl-LTs (LTC4, LTD4 and LTE4) as well as urinary LTE4 showed no significant differences compared with controls (P > 0.05). In addition, there was no significant association between CSF pleocytosis, clinical severity or time of disease onset. The increased concentration of LTB4 in the CSF of MS patients may indicate a biological importance for this mediator in MS.

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Citations

Oct 8, 2013·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sara Palumbo, Francesca Bosetti
Jun 6, 2012·Cell Research·Changsheng Du, Xin Xie
Sep 21, 2005·The Journal of Experimental Medicine·Suzana MarusicJames D Clark
Mar 17, 2010·Biochemical and Biophysical Research Communications·Yasuyuki KiharaTakao Shimizu
Jul 4, 2012·Cytokine·Ana Karolina de Santana NunesChristina Alves Peixoto
Mar 25, 2017·Nutritional Neuroscience·Sabrina EspositoGioacchino Tedeschi
Mar 20, 2010·Immunopharmacology and Immunotoxicology·Abbas Mirshafiey, Farhad Jadidi-Niaragh
Jan 25, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Karl-Erik EilertsenBjarne Østerud
Jul 13, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paresh ThakkerMina Hassan-Zahraee
Jun 10, 2020·Multiple Sclerosis and Related Disorders·Helena Beatriz FerreiraM Rosário Domingues

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