PMID: 8606397Mar 1, 1996Paper

Leukotrienes in the pathogenesis of pulmonary blast injury

The Journal of Trauma
I CernakI Ivanovic

Abstract

Our previous studies demonstrate a significant increase of sulfidopeptide leukotriene concentrations in animals exposed to a free air blast. The aim of this study was to analyze the role of leukotrienes in the local response of lung tissue as well as in the general response of organisms to blast overpressure. The study was conducted on adult rabbits exposed to moderate blast overpressure (four pulmonary contusions characterized as confluent ecchymoses involving 30 to 60% of the lungs), generated in laboratory conditions. One group of experimental animals was treated with 5-lipoxygenase (5-LO) inhibitor, diethylcarbamazine (DEC, Sigma, St. Louis, Missouri) (50 mg/kg, i.v.), immediately before blast. The early posttraumatic period was observed (30 minutes after blast). Hemodynamic parameters (mean arterial pressure, heart rate, blood gases) as well as arterial plasma levels of conjugated dienes were observed. The myeloperoxidase activity, lipid peroxidation products levels, and water contents were measured in the lung tissue of injured rabbits. We observed that 5-LO inhibition reduced edema formation, accumulation of neutrophils, and generation of lipid peroxidation products in injured lungs. In this study, we demonstrated that t...Continue Reading

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Citations

Jun 14, 2003·Neuroscience Research·Siri K Knudsen, Egil O Øen
May 14, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Gordana ZunićOlivera Jovanikić
Jun 27, 2006·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Marina VuceljićMiodrag Jevtić
Dec 11, 2013·Translational Stroke Research·Eric S Hald, Patrick W Alford
Oct 3, 2008·Medical Hypotheses·A C Courtney, M W Courtney
Mar 24, 2009·The Mount Sinai Journal of Medicine, New York·Gregory A Elder, Adrian Cristian
Nov 26, 2010·The British Journal of Surgery·C OwersJ P Garner
Feb 17, 2017·British Journal of Anaesthesia·T E ScottJ G Hardman
Aug 26, 1998·The Journal of Trauma·C B MoomeyK G Proctor
Jul 27, 1999·The Journal of Trauma·I CernakM Jevtic
Dec 10, 2017·Journal of Biomechanical Engineering·Elizabeth FievisohnPamela VandeVord
Mar 17, 2021·Scientific Reports·Usmah KawoosStephen T Ahlers

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