Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats

Neural Regeneration Research
Carmen Díaz GalindoJ Luis Quintanar

Abstract

Gonadotropin-releasing hormone (GnRH) and its synthetic analog leuprolide acetate, a GnRH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal cord compression injury were administered leuprolide acetate or saline solution for 5 weeks. At the 5(th) week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1(st) week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover. More importantly, leuprolide acetate treatment reduced microglial immunological reaction and induced a trend towards greater area of white and gray matter in the spinal cord. Therefore, leuprolide acetate has great potential to repair spinal cord injury.

References

Feb 1, 1995·Journal of Neurotrauma·D M BassoJ C Bresnahan
Jun 27, 2002·Clinical Pharmacokinetics·Piero PeritiEnrico Mini
Mar 17, 2004·Current Opinion in Neurobiology·Martin E Schwab
Apr 23, 2005·The Journal of Comparative Neurology·Minodora O Totoiu, Hans S Keirstead
Apr 25, 2006·Journal of Neurotrauma·Theo Hagg, Martin Oudega
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Jun 23, 2009·Neuroscience Letters·J Luis QuintanarRodolfo González
May 21, 2011·Experimental Neurology·William C de Groat, Naoki Yoshimura

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Citations

Jan 27, 2018·International Journal of Molecular Sciences·Carlos G Martínez-MorenoJosé Luis Quintanar
Sep 1, 2019·Digestive Diseases and Sciences·Moisés Altamira-CamachoJ Luis Quintanar
Apr 18, 2020·Growth Factors·María Del Carmen Díaz-GalindoJ Luis Quintanar
Aug 23, 2018·Neurourology and Urodynamics·Daniel Medina-AguiñagaJ Luis Quintanar

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Methods Mentioned

BETA
light microscopy

Software Mentioned

MacBiophotonics Image J
SigmaScan Pro
GraphPad
GraphPad Prism
AxioVision40V4

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