Leuprolide acetate lowers circulating bioactive luteinizing hormone and testosterone concentrations during ovarian stimulation for oocyte retrieval

Fertility and Sterility
M I CedarsD R Meldrum

Abstract

Levels of immunoreactive luteinizing hormone (LH), bioactive LH, and testosterone (T) were determined in 52 women receiving human menopausal gonadotropins (hMG). In 26 women receiving leuprolide acetate (LA) preceding hMG, there was a significant suppression of immunoreactive LH and bioactive LH. The characteristic increase in serum levels of bioactive LH and T were absent. Follicular fluid estradiol and T concentrations, and serum progesterone were not different. The lower circulating levels of T may reflect reduced LH-stimulated androgen accumulation in smaller nonaspirated follicles and may account for the enhanced follicle recruitment observed during LA. The lack of premature luteinization despite marked rises of bioactive LH in the absence of LA is consistent with normal events during the menstrual cycle and was due to the early termination of hMG stimulation.

Citations

Feb 4, 2006·Clinical Obstetrics and Gynecology·Dominique de ZieglerGabriel de Candolle
Dec 15, 2015·Journal of Obstetrics and Gynaecology of India·Gautam N Allahbadia
Sep 30, 1994·Annals of the New York Academy of Sciences·D De ZieglerP Bouchard
Dec 1, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Raoul OrvietoBenjamin Fisch
Dec 13, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Raoul OrvietoAntonio La Marca
Mar 1, 1995·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·D GrochowskiM Szamatowicz
Feb 26, 2005·Annals of the New York Academy of Sciences·Dominique de ZieglerFrancesco Bianchi-Demicheli

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