Leuprolide Acetate Release Study from γ-Irradiated PLGA-based In Situ Forming System

Current Drug Delivery
Mona ShapourganArezou Mashak

Abstract

It is well known that the properties of polymers can be altered by exposure to γ- ray. γ-irradiation has been used as a sterilization method for polymeric drug delivery devices, and its drug release profile must not be significantly changed. In this study, the effect of γ-irradiation on the release profile of leuprolide acetate from PLGA-based in situ forming system was investigated. Poly(lactide-co-glycolide) (PLGA) was dissolved in N-methylpyrrolidinone (NMP) and irradiated with a total dose of 8 kGy γ-ray emitted by a 60Co source. Then, leuprolide acetate was added to the polymer solution. PLGA-based in situ forming systems were prepared by injecting some specific amount of prepared solution into a buffer phosphate pH 7.4 at 37 °C. The effects of γ-ray on drug release profiles, morphology of matrices and thermal properties as well as stability of polymer were evaluated. The results showed that γ-irradiation causes a decrease in glass transition temperature (Tg) of PLGA from 43.4 to 38.1°C. A reduction in molecular weight of PLGA by about 17.8 % was found as consequence of radiolytic degradation. The morphological studies of PLGA matrices confirmed that the irradiated sample had higher porosity than the non-irradiated sample....Continue Reading

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