PMID: 11330611May 2, 2001Paper

Leuprolide acetate treatment of adrenocortical disease in ferrets

Journal of the American Veterinary Medical Association
R A WagnerJ W Oliver

Abstract

To determine the effects of leuprolide acetate, a long-acting gonadotropin-releasing hormone analog, in ferrets with adrenocortical diseases. Case series. 20 ferrets with adrenocortical disease diagnosed on the basis of clinical signs and plasma sex hormone concentrations. Ferrets were treated with leuprolide (100 microg, IM, once), and plasma hormone concentrations were measured before and 3 to 6 weeks after treatment. Leuprolide treatment resulted in significant reductions in plasma estradiol, 17 alpha-hydroxyprogesterone, androstenedione, and dehydroepiandrosterone concentrations and eliminated or reduced clinical signs associated with adrenocortical disease. Decreases in vulvar swelling, pruritus, and undesirable sexual behaviors and aggression were evident 14 days after treatment; hair regrowth was evident by 4 weeks after treatment. The response to treatment was transitory, and clinical signs recurred in all ferrets. Mean +/- SEM time to recurrence was 3.7 +/- 0.4 months (range, 1.5 to 8 months). Results suggest that leuprolide can be safely used to temporarily eliminate clinical signs and reduce sex hormone concentrations in ferrets with adrenocortical diseases. However, the safety of long-term leuprolide use in ferrets ...Continue Reading

Citations

Apr 1, 2004·Journal of Comparative Pathology·N J SchoemakerA Rijnberk
Nov 15, 2002·Molecular and Cellular Endocrinology·N J SchoemakerA Rijnberk
Jun 7, 2005·American Journal of Veterinary Research·Robert A WagnerJack W Oliver
Dec 6, 2006·Journal of the American Veterinary Medical Association·Jan C RamerJoanne Paul-Murphy
Jan 31, 2009·Journal of the American Veterinary Medical Association·Marion DesmarchelierIsabelle Langlois
Nov 28, 2013·The Veterinary Clinics of North America. Exotic Animal Practice·Sue ChenErin Culpepper
Nov 22, 2011·Molecular and Cellular Endocrinology·Felix BeuschleinDavid B Wilson
Feb 18, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Sharman M Hoppes
Jan 1, 2008·The Veterinary Clinics of North America. Exotic Animal Practice·Elisabeth Simone-Freilicher
Oct 9, 2007·Domestic Animal Endocrinology·N J SchoemakerS Galac
Mar 17, 2007·Molecular and Cellular Endocrinology·Harold E Carlson
Dec 17, 2014·Molecular and Cellular Endocrinology·Theresa RöhrigDavid B Wilson
Jun 4, 2015·Endocrinology and Metabolism Clinics of North America·Sara Galac, David B Wilson
Apr 26, 2016·American Journal of Veterinary Research·Kristina W CalicchioJeffrey A Solomon
Nov 8, 2018·Endocrine-related Cancer·Milena DoroszkoNafis A Rahman
Mar 7, 2007·Journal of the American Animal Hospital Association·Andrea Maria KuijtenGeorge Voorhout
Dec 5, 2020·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Sabrina Stempel, Sandra Goericke-Pesch

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