PMID: 8609094Jan 1, 1996Paper

Leustroduscin B, a new cytokine inducer derived from an actinomycetes, induces thrombocytosis in mice

The Journal of Antibiotics
Takafumi KohamaK Yamashita

Abstract

Leustroduscin B (LSN-B), a novel colony-stimulating factor (CSF) inducer produced by an actinomycetes, has previously been shown to induce CSF production in bone marrow stromal cells. To determine the biological activity of LSN-B on hematopoiesis in vivo, LSN-B was administered intraperitoneally to mice every day for three to six days. Peripheral platelet counts were markedly elevated on days 4 through 6 compared with the control mice injected with vehicle. Serum II/6 levels were low (0.8 ng/ml) or virtually undetectable in the drug treated groups. This cytokine profile suggests that LSN-B induction of thrombocytosis is mechanistically distinct from other cytokine inducers such as IL-1 or FK-565.

Citations

May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ryuta KoishiNobufusa Serizawa
Nov 11, 1998·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·R KoishiT Kohama
Apr 13, 2006·Journal of Industrial Microbiology & Biotechnology·Mohini GhatgeKevin Reynolds
Nov 19, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Leyla Mohammadkhani, Majid M Heravi
Jun 14, 2008·The Journal of Organic Chemistry·Kazuyuki MiyashitaTakeshi Imanishi
Nov 4, 2009·The Journal of Organic Chemistry·MinJin KangMichael D Burkart
Sep 21, 2010·Organic Letters·Brian D JonesMichael D Burkart
May 20, 2011·Organic Letters·Stephen N GreszlerJeffrey S Johnson
Aug 28, 2015·Journal of the American Chemical Society·Barry M TrostMing-Yu Ngai
Dec 29, 2016·Chemical Reviews·Barry M TrostCheyenne S Brindle
Apr 3, 2003·Journal of the American Chemical Society·Kousei ShimadaTohru Fukuyama

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