PMID: 403486Apr 1, 1977

Levamisole and hamster pouch carcinogenesis

Oral Surgery, Oral Medicine, and Oral Pathology
E Eisenberg, G Shklar

Abstract

Seventy-five male and female Syrian hamsters (Cricetus auratus), 10 months of age, were studied for the effects of systemically administered levamisole upon the process of chemical carcinogenesis of buccal pouch mucosa. In twenty-five animals (Group II) the left buccal pouch was painted three times weekly with a 0.5 per cent solution of 9,10-dimethyl-1,2-benzanthracene (DMBA) in heavy mineral oil. After each topical application of carcinogen to the buccal pouch, animals in Group II received approximately 0.7 mg. of levamisole hydrochloride orally by means of a pipette. In another twenty-five animals (Group I) the left buccal pouch was painted three times weekly with DMBA, but they were not given levamisole. The twenty-five animals in Group III served as untreated controls. In those animals which received levamisole chemical carcinogenesis of the buccal pouch was retarded. Fewer tumors developed, and they were of smaller size.

References

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Citations

Sep 1, 1982·Oral Surgery, Oral Medicine, and Oral Pathology·W Weerapradist, G Shklar
Jan 1, 1993·European Journal of Cancer. Part B, Oral Oncology·G Shklar, J Schwartz
Jan 1, 1995·European Journal of Cancer. Part B, Oral Oncology·T Tanaka
Jan 1, 1995·European Journal of Cancer. Part B, Oral Oncology·C Scully
Jul 1, 1996·European Journal of Cancer. Part B, Oral Oncology·S V Kandarkar, S S Sawant
Jan 1, 1983·Nutrition and Cancer·A Burge-Bottenbley, G Shklar
Jan 1, 1988·Nutrition and Cancer·J SchwartzD Trickler
Jan 1, 1990·Nutrition and Cancer·C L Meng, K W Shyu
Feb 1, 1978·Journal of Oral Pathology·M P Marefat, G Shklar
Feb 7, 2001·Cancer Investigation·G Shklar, S K Oh
Oct 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Alexey KozlenkovJose Luis Millán
Jul 20, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sonoko NarisawaJose Luis Millán
Jan 1, 1978·Archives of Oral Biology·S PisantyG Shklar
Jul 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·G ShklarK D Wallace
Feb 1, 1982·Oral Surgery, Oral Medicine, and Oral Pathology·T M Perkins, G Shklar
Jun 1, 1988·Oral Surgery, Oral Medicine, and Oral Pathology·E G MillerJ M Wright
Nov 1, 1978·Oral Surgery, Oral Medicine, and Oral Pathology·J B Murphy, J Giunta
Jun 1, 1979·Oral Surgery, Oral Medicine, and Oral Pathology·L P MerkJ Albright
Oct 1, 1977·Oral Surgery, Oral Medicine, and Oral Pathology·P Marefat, G Shklar
May 1, 1985·Oral Surgery, Oral Medicine, and Oral Pathology·M M HassanG Szabo
Jan 1, 1986·Journal of Oral Pathology·H Maeda, Y Kameyama
Feb 1, 1979·Journal of Dental Research·J A CottoneS M Standish
Jun 1, 1981·Journal of Oral Pathology·J W Eveson
Dec 1, 1981·The Journal of Dermatologic Surgery and Oncology·C L MengG Shklar
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Related Concepts

Benz(a)Anthracenes
Carcinomatosis
Cricetus
Solaskil
Malignant Neoplasm of Mouth
Neoplasms, Experimental
9,10-Dimethyl-1,2-benzanthracene

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