Levamisole exacerbates coxsackievirus B3-induced murine myocarditis.

Infection and Immunity
R J GudvangenC J Gauntt

Abstract

Levamisole administration to several strains of adolescent mice at the time of or up to 4 days post-inoculation (p.i.) with a myocarditic variant of coxsackievirus B3 (CVB3m) increased the number of myocarditic lesions above that found in CVB3m-inoculated mice. Virus replication in heart tissues in vivo was not affected by levamisole administration to the mice, nor was production of neutralizing antibody to CVB3m. Lymphocytes from nodes of virus-inoculated mice treated with levamisole at 2 days p.i. exhibited an increased reactivity to phytohemagglutinin on days 6 and 8 p.i., compared with respective responses by nodal T lymphocytes from CVB3m-inoculated mice. Levamisole treatment of CVB3m-inoculated mice also increased the reactivity of splenic and peripheral blood T lymphocytes to phytohemagglutinin on day 8 p.i., but not day 6 p.i., compared with the respective responses by lymphocytes from CVB3m-inoculated mice. The proportion of theta antigen-bearing lymphocytes in the total lymphocyte population in peripheral blood of CVB3m-inoculated mice was not altered by levamisole treatment. However, CVB3m-induced reduction in this subpopulation of lymphocytes in the nodes was restored to control levels by levamisole treatment. React...Continue Reading

References

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Citations

Oct 1, 1986·Journal of Medical Virology·E K GodenyC J Gauntt
Jun 27, 2003·Current Opinion in Cardiology·Bilal AyachPeter Liu
Jan 1, 1985·Journal of Interferon Research·C W Lutton, C J Gauntt
Jan 1, 1989·Immunologic Research·L J Wolfgram, N R Rose
Feb 1, 1985·Antimicrobial Agents and Chemotherapy·C J GaunttU O Cheriyan

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