Levamisole inhibits angiogenesis in vitro and tumor growth in vivo

Angiogenesis
Tina FriisGunnar Houen

Abstract

The synthetic anthelmintic compound Levamisole has previously been used in cancer treatment as an adjuvant in combination with 5-fluorouracil. Its mode of action remains unclear, but an immune-stimulatory effect has been suggested. Here, we show that Levamisole inhibits angiogenesis in vitro and tumor growth in vivo. In vitro, Levamisole specifically inhibits proliferation and differentiation of endothelial cells propagated in co-culture with fibroblasts. In vivo, Levamisole inhibits the growth in nude mice of a transplanted human tumor. The use of nude mice as tumor hosts permits the discrimination between the angiogenesis inhibitory effect of Levamisole and its assumed immune-stimulatory effect. Our findings support a possible therapeutic effect of angiogenesis inhibitors in the treatment of cancer and call for further investigations of the mechanism(s) underlying the anti-angiogenic effect of Levamisole.

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Citations

Aug 7, 2007·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·G OcalB Kandemir
Apr 29, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tina FriisAnne-Marie Engel
Jan 1, 2010·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Lene SylvestGunnar Houen
Apr 29, 2015·Case Reports in Pulmonology·Shehabaldin AlqalyoobiAshraf Gohar
Oct 24, 2017·Immunological Investigations·Christine RuhJohn K Crane
Aug 5, 2020·Journal of Cellular Biochemistry·Susana G GuerreiroCharles J Kirkpatrick
Dec 11, 2020·Therapeutic Drug Monitoring·Kari M MidthunBarry K Logan

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Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.