Levamisole tainted cocaine causing severe neutropenia in Alberta and British Columbia.

Harm Reduction Journal
Lewinda KnowlesJames Talbot

Abstract

Five cases of severe neutropenia (neutrophil counts < 0.5 per 109 cells/L) associated with exposure to cocaine and levamisole, an antihelimithic agent no longer available in Canada, were identified in Alberta in 2008. Alberta and British Columbia (BC) public health officials issued an advisory and urged health care professionals to report cases to public health. This paper presents the findings of the public health investigations. Cases were identified prospectively through reporting by clinicians and a retrospective review of laboratory and medical examiners data from January 1, 2006 to March 31, 2009. Cases were categorized as confirmed, probable or suspect. Only the confirmed and probable cases are included in this paper. We compare cases of severe neutropenia associated with tainted cocaine (NATC) identified in Alberta and BC between January 1, 2008 to March 31, 2009. Of the 42 NATC cases: 23(55%) were from Alberta; 19(45%) were from British Columbia; 57% of these cases reported crack cocaine use (93% of those who identified type of cocaine used); 7% reported using cocaine powder; and the main route of cocaine administration was from smoking (72%). Fifty percent of the NATC cases had multiple episodes of neutropenia associa...Continue Reading

References

Dec 1, 1978·Klinische Wochenschrift·K L SchmidtH Breithaupt
Jan 1, 1986·Biopharmaceutics & Drug Disposition·E KouassiM Vézina
Feb 1, 1980·Annals of the Rheumatic Diseases·S I DrewP I Terasaki
Mar 1, 1995·Food Additives and Contaminants·M D RoseW H Farrington
Nov 1, 1995·Food Additives and Contaminants·M D RoseG Shearer
Oct 21, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S SpectorD E Schmidt
Jun 18, 2003·European Journal of Pharmacology·Mark M LevandoskiJane Chang
Aug 8, 2007·Forensic Science International : Synergy·Nadia Fucci
May 27, 2008·Annals of Emergency Medicine·Robert S HoffmanUNKNOWN Clenbuterol Study Investigators
Jan 21, 2009·Annals of Internal Medicine·Nancy Y ZhuA Robert Turner

❮ Previous
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Citations

Jun 28, 2011·Clinical Rheumatology·Rachel L GrossChaim Putterman
Jan 19, 2013·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Omar MetwallyThomas Lall
Nov 19, 2011·The American Journal of Dermatopathology·Reza S JacobMeera Mahalingam
Dec 7, 2011·Current Opinion in Hematology·Jennie A Buchanan, Eric J Lavonas
Oct 30, 2013·Plastic and Reconstructive Surgery·Ashley N AmalfiErika A Henkelman
May 21, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Erin SchillbergSalaheddin M Mahmud
Jan 25, 2013·Case Reports in Rheumatology·Alfredo Sánchez-CruzJose Gutierrez-Nuñez
Feb 13, 2016·Forensic Science International : Synergy·Francesca IndoratoNunziata Barbera
Aug 15, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alan Hb WuKara L Lynch
Mar 30, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Alexandre Larocque, Robert S Hoffman
Aug 6, 2011·The American Journal of the Medical Sciences·Seby JohnDavid Hamrock
Feb 13, 2013·Journal of the American Academy of Dermatology·Cara Hennings, Jami Miller
Jan 10, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Kelly R MaglioccaSareeta R Parker
Dec 14, 2011·Seminars in Arthritis and Rheumatism·Tahir A KhanCharles V Sanders
Sep 17, 2011·Journal of the American Academy of Dermatology·Kachiu C LeeMargaret Kessler
Aug 27, 2011·Seminars in Arthritis and Rheumatism·Samuel H PoonAnthony M Reginato
Jul 20, 2011·Forensic Science International : Synergy·Serge Schneider, François Meys
Apr 22, 2011·Seminars in Arthritis and Rheumatism·Peter C GraysonPeter A Merkel
May 18, 2010·Medicina clínica·Mireia Ventura VilamalaUNKNOWN Grupo Investigadores SELECTO
Feb 16, 2011·Drug Testing and Analysis·Claire ColeMark Bellis
Aug 27, 2010·Journal of Cutaneous Pathology·Noreen M G WalshJohn G Hanly
Aug 24, 2013·International Journal of Dermatology·David R CroweDiya F Mutasim
Jan 29, 2014·Drug Testing and Analysis·Claudio Vidal GinéMireia Ventura Vilamala
Aug 1, 2015·Archives of Pathology & Laboratory Medicine·Jordan A Roberts, Patricia Chévez-Barrios
Jun 14, 2015·BMC Research Notes·Jane A BuxtonBruce Carleton
Jul 19, 2011·International Journal of Cardiology·Steven B KarchElisabetta Bertol
Aug 19, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·I de la HeraF Vanaclocha
Dec 6, 2011·Journal of Burn Care & Research : Official Publication of the American Burn Association·Russell W FarmerGlen A Franklin
Dec 7, 2017·Current Opinion in Hematology·Michael J Cascio, Kuang-Yu Jen
Oct 8, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Martina M McGrathJohn L Niles
Jun 10, 2011·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Ulrich Specks
Jan 24, 2013·Annals of Plastic Surgery·Justyn LutfyMario Jarmuske
Jul 30, 2010·Clinical Pharmacology and Therapeutics·A ChangJ Thomas
Mar 21, 2017·Archives of Toxicology·Tibor Markus BruntBastiaan Venhuis
May 28, 2011·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Nicholas A ZwangShawn Rose
Nov 30, 2018·Journal of Forensic Sciences·Taís R FiorentinBarry K Logan
Sep 1, 2018·Seminars in Arthritis and Rheumatism·Anaïs DartevelLuc Mouthon
Aug 17, 2021·Journal of Clinical Pharmacology·C Michael WhiteAnne N Nafziger
Sep 17, 2021·BMC Public Health·Emily BiggarJane A Buxton

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Methods Mentioned

BETA
biopsies
biopsy
flow cytometry

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