PMID: 6972083Jan 1, 1980Paper

Levamisole therapy for HBsAg-positive chronic liver disease

Scandinavian Journal of Gastroenterology
R G ChadwickS Sherlock

Abstract

Eight subjects with HBsAg-positive chronic liver disease received levamisole therapy continuously for 6 to 8 weeks. Depressed T-lymphocyte concentrations, found in all patients before therapy, transiently returned towards normal. All of the three patients who had normal delayed hypersensitivity responses before treatment showed an acute hepatitic reaction manifested by elevation of serum aspartate transaminase (AsT) and HBsAg levels, with transient cell-mediated immunity to HBsAg. This was interpreted as indicating increased lysis of infected hepatocytes. All of the five anergic patients showed no change in AsT or HBsAg levels. The clinical features and hepatic histology were unchanged. In patients with the capacity to mount normal delayed hypersensitivity responses, levamisole enhanced the cell-mediated response to HBsAg, and there was increased lysis of infected cells. Nevertheless, this treatment failed to eradicate the virus, as all patients remained HBsAg-positive.

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Citations

Jul 9, 1999·Reviews in Medical Virology·A R Marques, S E Straus
Jan 1, 1986·Antimicrobial Agents and Chemotherapy·M EisenbergT C Merigan
Sep 10, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Azza El Sherbini, Asmaa Omar
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M G MutchnickD A Shafritz
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Ruiz-MorenoV Carreño

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