PMID: 2484125Jan 1, 1989Paper

Level of fetal hemoglobin as an indicator of clinical complications in sickle cell anemia

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
J O BordinR Sesso

Abstract

1. The fetal hemoglobin (HbF) level was used as an indicator of the development of severe clinical complications in 89 patients with sickle cell anemia (SCA). 2. HbF was determined by the alkali denaturation technique. The mean HbF level was 6.7 +/- 4.2% (range, 0.7 to 19.2%) of total hemoglobin. 3. Major organ failures were considered to be terminal events of morbidity and included 8 cerebrovascular accidents, 13 aseptic necroses of the femoral head and 17 leg ulcer episodes. 4. The characteristics of the test, including sensitivity, specificity and positive predictive value were analyzed for different levels of HbF. 5. The overall specificities were 76, 76, and 85% for HbF levels greater than or equal to 8, 10 and 12%, respectively. The sensitivity of the test was low. The positive predictive value reached 71% for children with HbF greater than or equal to 8%. The data suggest that HbF level may be a useful indicator of the possibility of a patient developing serious clinical complications.

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