Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast

FEBS Letters
A M AertsK Thevissen

Abstract

The antifungal plant defensin DmAMP1 interacts with fungal sphingolipids of mannosyldiinositolphosphorylceramide (M(IP)2C) class. We screened a Saccharomyces cerevisiae transposon (Tn) mutant library against DmAMP1 and identified one DmAMP1-resistant mutant with the Tn inserted in the M(IP)2C biosynthesis gene IPT1 (DmTn11) and one DmAMP1-hypersensitive mutant with the Tn inserted in rDNA (HsTnII). However, tetrad analysis pointed to HsTnII as a spontaneous mutant. Apparently, membranes of DmTn11 lack M(IP)2C, whereas membranes of HsTnII have increased M(IP)2C levels. In addition, DmTn11 and HsTnII are characterized by increased and reduced oxidative stress resistance/chronological life-span (CL), respectively. A putative involvement of M(IP)2C in oxidative stress and CL in yeast is discussed.

References

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Citations

Aug 20, 2009·Transgenic Research·Sanjay Jha, Bharat B Chattoo
Jul 10, 2008·BMC Plant Biology·Abré de Beer, Melané A Vivier
Feb 10, 2012·PLoS Genetics·Xinhe HuangRobert C Dickson
Mar 22, 2007·Planta·Axel de ZélicourtPhilippe Delavault
Aug 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kim VriensKarin Thevissen
Dec 19, 2015·FEMS Yeast Research·Dhanabalan KanagavijayanMalathi Srinivasan
May 6, 2015·Biochimica Et Biophysica Acta·Kiterie M E FallerMichael Bond
Aug 10, 2016·Future Medicinal Chemistry·Rodrigo Rollin-PinheiroMaurizio Del Poeta
May 29, 2014·FEMS Yeast Research·Natalia S VoynovaAndreas Conzelmann
Nov 8, 2013·Molecular Biology of the Cell·Erwin SwinnenJoris Winderickx
Nov 30, 2012·Biopolymers·Annia AlbaAnselmo J Otero-González
May 23, 2013·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Maki YamagataAkio Kihara
Feb 20, 2017·The Journal of Membrane Biology·Elena Ermakova, Yuriy Zuev
Nov 4, 2020·FEBS Letters·Filipa C SantosRodrigo F M de Almeida
Apr 30, 2021·Frontiers in Cell and Developmental Biology·Caroline StruyfsKarin Thevissen

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