PMID: 15374377Jul 1, 1992Paper

Level of NK cytotoxic activity in the elderly aged more than 80 years

Archives of Gerontology and Geriatrics
Jolanta MyśliwskaAndrzej Myśliwski

Abstract

A group of healthy volunteers aged 60-93 years, was evaluated with respect to their NK activity. These people have been under careful medical observation for 3 years and were selected according to Senieur Protocol criteria. NK activity of each person was checked at least three times at regular 12-month intervals with the chromium release test and twice at the same interval of time with a single cell cytotoxicity assay. NK activity of 60-79-year-old females was in a similar range of values as that of young females (20-35 years) and was lower than that of the males of the corresponding age groups. The females aged 80-88 years revealed the highest NK activity. The chronically ill 80-88-year-old females, on the other hand, were characterized by a marked decrease of NK activity in relation to their age counterparts. NK activity of both the females and males significantly declined at the age of 89-93 years. The significance of NK activity for survival is discussed.

References

May 1, 1990·Journal of Gerontology·L LehtonenA Lehtonen
Jan 1, 1985·International Journal of Immunopharmacology·K Y TsangH H Fudenberg
Jan 1, 1988·Annals of the New York Academy of Sciences·G DoriaD Frasca
Nov 1, 1984·Mechanisms of Ageing and Development·G J LigthartG G Steinmann
Jul 1, 1984·Immunology Today·M J Colston

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