Level of pleural invasion effects on prognosis in lung cancer

Tumori
Serhan TanjuŞükrü Dilege

Abstract

To analyze the extent of visceral pleural invasion (VPI) and its effect on survival along with its place in determining the T descriptor in TNM staging in our patients. A total of 233 patients underwent lung resection. The data were retrospectively analyzed in terms of sex, age, histopathologic type, stage of the tumor, extent of VPI, and survival. Patients who had neoadjuvant chemotherapy or chemoradiotherapy, distant metastasis, parietal pleural invasion, and operative mortality were excluded. The median follow-up was 59 months (range 4-126). The extent of VPI was PL0 in 119 (65.7%) patients, PL1 in 47 (26%) patients, and PL2 in 15 (8%) patients. The median survival rates were 65 (range 43-96) months for PL0, 54 (range 37-72) months for PL1, and 39 (range 12-69) months for PL2. The 5-year overall survival rates were 74.7% for PL0, 77.8% for PL1, and 53.3% for PL2. There were statistically significant differences in overall survival among PL0, PL1, and PL2 ( p = 0.03). In subgroup analysis, the difference was insignificant in PL0 vs PL1 ( p = 0.81), but significant in PL0 vs PL2 ( p = 0.02) and PL1 vs PL2 ( p = 0.04) groups. This study emphasizes that the presence of VPI is related with poor prognosis independent of lymph node...Continue Reading

References

Apr 20, 2001·The Annals of Thoracic Surgery·D Manac'hC Danel
Apr 28, 2004·The Annals of Thoracic Surgery·Toshihiro OsakiKosei Yasumoto
Jun 3, 2004·The Journal of Thoracic and Cardiovascular Surgery·Kimihiro ShimizuYutaka Nishiwaki
Jul 4, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ramón Rami-PortaUNKNOWN Participating Institutions
Sep 23, 2008·The Annals of Thoracic Surgery·Noriaki SakakuraTetsuya Mitsudomi
Dec 6, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN International Staging Committee
Sep 5, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yujin KudoNorihiko Ikeda
Mar 15, 2013·Japanese Journal of Clinical Oncology·Mayumi OyamaHitoshi Tsuda
Jan 8, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Hiroyuki AdachiMunetaka Masuda
Jul 3, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ramón Rami-PortaUNKNOWN IASLC Staging and Prognostic Factors Committee, Advisory Boards and Participating Institutions

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BETA
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Statistical Package for Social Sciences ( SPSS )
SPSS Statistics Data Editor

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