Level of tau protein in children treated for acute lymphoblastic leukemia

Pediatric Neurology
Katarzyna Muszyńska-RosłanAdam Hołownia

Abstract

Long-term neuropsychological complications such as attention and concentration disturbances, poor school performance, hyperexcitability, and even leukoencephalopathy have been described in children after chemotherapy for acute lymphoblastic leukemia. Elevation of the cerebrospinal fluid level of tau protein, associated with neuronal axons, is a neurodegenerative marker. The aim of the study was to assess the level of cerebrospinal fluid tau protein in children with acute lymphoblastic leukemia. The study included 26 patients with acute lymphoblastic leukemia and 19 patients with clinical symptoms of cerebrospinal meningitis (reference group). Tau protein levels were determined by enzyme-linked immunosorbent assay. Cerebrospinal fluid total protein level was not elevated in any of the samples. The examination was performed at diagnosis, after induction treatment, during consolidation, and after reinduction, i.e. before maintenance therapy. Neither age nor sex had an effect on tau protein levels in both groups. The mean tau protein value at diagnosis was 244.84 +/- 98.96 pg/mL in the study group (norm 300 pg/mL) and produced no correlation with initial leukocytosis, lactate dehydrogenase activity, or organomegaly at this point. D...Continue Reading

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Citations

Mar 1, 2013·Pathology Oncology Research : POR·Qiong WangDan Wu
Jul 6, 2013·Pediatric Neurology·Pashtun ShahimNiklas Mattsson
Oct 3, 2012·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Pashtun ShahimNiklas Mattsson
Dec 11, 2008·Pediatric Neurology·Peter D ColeBarton A Kamen
Jul 10, 2018·Journal of the National Cancer Institute·Iris ElensJurgen Lemiere

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