Levelling the Translational Gap for Animal to Human Efficacy Data

Animals : an Open Access Journal From MDPI
Guilherme S FerreiraPeter J K Van Meer

Abstract

Reports of a reproducibility crisis combined with a high attrition rate in the pharmaceutical industry have put animal research increasingly under scrutiny in the past decade. Many researchers and the general public now question whether there is still a justification for conducting animal studies. While criticism of the current modus operandi in preclinical research is certainly warranted, the data on which these discussions are based are often unreliable. Several initiatives to address the internal validity and reporting quality of animal studies (e.g., Animals in Research: Reporting In Vivo Experiments (ARRIVE) and Planning Research and Experimental Procedures on Animals: Recommendations for Excellence (PREPARE) guidelines) have been introduced but seldom implemented. As for external validity, progress has been virtually absent. Nonetheless, the selection of optimal animal models of disease may prevent the conducting of clinical trials, based on unreliable preclinical data. Here, we discuss three contributions to tackle the evaluation of the predictive value of animal models of disease themselves. First, we developed the Framework to Identify Models of Disease (FIMD), the first step to standardise the assessment, validation a...Continue Reading

References

Aug 1, 1969·Archives of General Psychiatry·W T McKinney, W E Bunney
Jan 1, 1984·Psychopharmacology·P Willner
Jun 5, 2003·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Vik BebartaKennon Heard
Feb 28, 2004·BMJ : British Medical Journal·Pandora PoundUNKNOWN Reviewing Animal Trials Systematically (RATS) Group
Aug 3, 2004·Nature Reviews. Drug Discovery·Ismail Kola, John Landis
Jan 27, 2007·BMJ : British Medical Journal·Daniel G Hackam
Apr 3, 2010·PLoS Medicine·H Bart van der WorpMalcolm R Macleod
Jul 7, 2010·Alternatives to Laboratory Animals : ATLA·Orsolya E VargaI Anna S Olsson
Sep 6, 2011·Nature Reviews. Drug Discovery·Florian PrinzKhusru Asadullah
Mar 31, 2012·Nature·C Glenn Begley, Lee M Ellis
Jun 9, 2012·Nature Biotechnology·Jonathan Kimmelman, James A Anderson
Feb 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Junhee SeokUNKNOWN Inflammation and Host Response to Injury, Large Scale Collaborative Research Program
Nov 20, 2013·Nature Reviews. Neurology·David W HowellsMalcolm R Macleod
Jan 16, 2014·PloS One·Roderik F ViergeverDavina Ghersi
Mar 29, 2014·BMC Medical Research Methodology·Carlijn R HooijmansMiranda W Langendam
Mar 29, 2014·Nature·Steve Perrin
Dec 3, 2014·Drug Discovery Today·Caroline J Zeiss
Jan 2, 2015·Circulation Research·C Glenn Begley, John P A Ioannidis
Mar 6, 2015·Disease Models & Mechanisms·Joe W McGreevyDongsheng Duan
Mar 31, 2015·European Journal of Pharmacology·Peter J K van MeerHenk-Jan Schuurman
Jun 10, 2015·PLoS Biology·Leonard P FreedmanTimothy S Simcoe
Oct 16, 2015·PLoS Biology·Malcolm R MacleodEmily S Sena
Oct 16, 2015·Journal of Medical Ethics·Jonathan Kimmelman, Valerie Henderson
Feb 6, 2017·Nature·Jonathan Kimmelman, Carole Federico
Feb 14, 2017·JAMA : the Journal of the American Medical Association·John P A Ioannidis
Aug 5, 2017·Laboratory Animals·Adrian J SmithTrond Brattelid
Feb 3, 2018·Biostatistics·Chi Heem WongAndrew W Lo
May 8, 2018·Regulatory Toxicology and Pharmacology : RTP·Matthew Clark, Thomas Steger-Hartmann
Nov 9, 2018·Journal of Translational Medicine·Pandora Pound, Merel Ritskes-Hoitinga
Jan 12, 2019·ALTEX·Thomas HartungMarcel Leist
Mar 19, 2019·Drug Discovery Today·Malcolm Haddrick, Peter B Simpson
Mar 29, 2019·Genome Biology·Benjamin E Mead, Jeffrey M Karp
Jun 18, 2019·Research Integrity and Peer Review·Kaitlyn HairUNKNOWN IICARus Collaboration
Jul 11, 2019·European Journal of Pharmacology·Désirée H Veening-GriffioenHuub Schellekens
Jul 17, 2019·Journal of Translational Medicine·Cathalijn H C LeenaarsFranck L B Meijboom

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Citations

May 1, 2021·International Journal of Molecular Sciences·Katrina AlbertŠárka Lehtonen
May 18, 2021·Frontiers in Bioengineering and Biotechnology·Hye Sook ShinYasuhiro Shudo
Sep 1, 2021·Critical Reviews in Toxicology·Marlon R SchneiderRob J Vandebriel

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Software Mentioned

FIMD
PREPARE
derisk
ARRIVE
SYstematic Review Center for Laboratory animal Experimentation...
IB

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