Levels of angiogenesis-related vascular endothelial growth factor family in neovascular glaucoma eyes

Acta Ophthalmologica
Shida ChenXiulan Zhang

Abstract

This study aimed to evaluate the angiogenesis-related factors of the vascular endothelial growth factor (VEGF) family in the aqueous humour of patients with neovascular glaucoma (NVG). This study involved 22 eyes of 22 patients with advanced NVG requiring antiglaucomatous surgery and 20 control subjects with cataracts. The NVG eyes received an intravitreal injection of ranibizumab (IVR) treatment before antiglaucomatous surgery. Aqueous humour and blood were collected at the time of IVR and cataract surgery. Protein concentration of VEGF-A, VEGF-B and placenta growth factor (PlGF) in aqueous humour and plasma was determined by ELISA tests. The mean concentration (standard deviation) of VEGF-A and PlGF in the aqueous humour of patients with NVG were 3037 (2387) pg/ml and 1078 (712) pg/ml, respectively; both were significantly higher than the control group (both p < 0.001). However, levels of VEGF-A and PlGF in the serum of NVG and control subjects remained low. High concentrations of VEGF-A were closely correlated with high levels of PlGF in patients with NVG (r = 0.593, p = 0.004). Concentrations of VEGF-B in aqueous humour and serum remained unchanged (p > 0.05). There were high concentrations of angiogenesis factors of the VE...Continue Reading

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Citations

Jan 31, 2016·Acta Ophthalmologica·Satoshi KinoshitaSusumu Ishida
May 22, 2018·Expert Opinion on Biological Therapy·Andreas KatsanosAnastasios G P Konstas
Jan 6, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tulay Simsek, Mustafa Değer Bilgeç
Mar 12, 2021·Pharmacology Research & Perspectives·María L FormicaSantiago D Palma

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