Levels of antibodies against human heat shock protein (HSP) 60 in patients with glaucoma in Poland

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Iwona Grabska-LiberekBarbara Czarnocka

Abstract

Although elevated intraocular pressure is a major risk factor for the development of glaucoma, there is increasing evidence that the immune system may be involved in the development of normal-tension glaucoma (NTG). The aim of this study was to determine if NTG is associated with elevated levels of antibodies against human heat shock protein (HSP) 60. The study was conducted in 139 subjects (35 subjects with NTG [Group 1], 34 subjects with primary open-angle glaucoma /POAG/ [Group 2], 24 subjects with autoimmune rheumatic diseases [Group 3], and 36 healthy controls [Group 4]). All subjects had complete ophthalmologic examination (visual acuity, slit-lamp examination, tonometry, gonioscopy; visual-field examination, and optical coherence tomography /OCT/ of the optic nerve head and the macula). Blood samples were collected for the measurements of serum levels of antibodies against human HSP60. The subjects with rheumatic diseases had the highest median serum level of antibodies against HSP60 - 20.49 ng/mL. The values in the subjects with NTG, POAG, and in controls were 18.79 ng/mL, 18.61 ng/mL and 17.61 ng/mL, respectively (p=0.96). This study does not confirm the hypothesis that normal-tension glaucoma is associated with elevat...Continue Reading

References

Aug 1, 1992·Current Opinion in Immunology·D B Young
Jun 10, 2000·Current Opinion in Ophthalmology·M B Wax
Jan 30, 2002·The British Journal of Ophthalmology·Paul J FosterGordon J Johnson
Mar 24, 2004·Brain Research Bulletin·Gülgün TezelMartin B Wax
May 26, 2004·Lancet·Robert N Weinreb, Peng Tee Khaw
Apr 29, 2006·Survey of Ophthalmology·Mona Pache, Josef Flammer
Feb 1, 2007·Chemical Immunology and Allergy·Gülgün Tezel, Martin B Wax
Oct 30, 2009·Autoimmunity·Georgios Foteinos, Qingbo Xu
Aug 31, 2010·Experimental Eye Research·Martin B Wax
Dec 15, 2010·Trends in Immunology·Francisco J Quintana, Irun R Cohen
Apr 2, 2011·Lancet·Harry A Quigley
Apr 22, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Cecilia GrundtmanGeorg Wick
Aug 17, 2011·Brain, Behavior, and Immunity·Nils BoehmFranz H Grus
Nov 15, 2011·Current Pharmaceutical Design·Manfredi RizzoFrancesco Cappello
Jun 8, 2012·Atherosclerosis·Giuseppe MurdacaFrancesco Puppo
Jul 14, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Katarzyna SkoniecznaAgnieszka Jamrozy-Witkowska

❮ Previous
Next ❯

Citations

Dec 20, 2015·Restorative Neurology and Neuroscience·Anna Wójcik-GryciukWioletta J Waleszczyk
Mar 29, 2016·Progress in Retinal and Eye Research·Natik PiriJoseph Caprioli
Oct 23, 2019·International Journal of Molecular Sciences·Teresa TsaiStephanie C Joachim

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunoabsorbent assay

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.